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Rift Valley Fever

Rift Valley fever
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Defibition:
Rift Valley Fever (RVF) is a viral zoonosis (affects primarily domestic livestock, but can be passed to humans) causing fever. It is spread by the bite of infected mosquitoes, typically the Aedes or Culex genera.

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The disease is caused by the RVF virus, a member of the genus Phlebovirus (family Bunyaviridae). The disease was first reported among livestock in Kenya around 1915, but the virus was not isolated until 1931. RVF outbreaks occur across sub-Saharan Africa, with outbreaks occurring elsewhere infrequently (but sometimes severely – in Egypt in 1977-78, several million people were infected and thousands died during a violent epidemic. In Kenya in 1998, the virus claimed the lives of over 400 Kenyans. In September 2000 an outbreak was confirmed in Saudi Arabia and Yemen).

In humans the virus can cause several different syndromes. Usually sufferers have either no symptoms or only a mild illness with fever, headache, myalgia and liver abnormalities. In a small percentage of cases (< 2%) the illness can progress to hemorrhagic fever syndrome, meningoencephalitis (inflammation of the brain), or affecting the eye. Patients who become ill usually experience fever, generalized weakness, back pain, dizziness, and weight loss at the onset of the illness. Typically, patients recover within 2-7 days after onset.

RVF virus is a member of the Phlebovirus genus, one of the five genera in the family Bunyaviridae. The virus was first identified in 1931 during an investigation into an epidemic among sheep on a farm in the Rift Valley of Kenya. Since then, outbreaks have been reported in sub-Saharan and North Africa. In 1997-98, a major outbreak occurred in Kenya, Somalia and Tanzania and in September 2000, RVF cases were confirmed in Saudi Arabia and Yemen, marking the first reported occurrence of the disease outside the African continent and raising concerns that it could extend to other parts of Asia and Europe.

Approximately 1% of human sufferers die of the disease. Amongst livestock the fatality level is significantly higher. In pregnant livestock infected with RVF there is the abortion of virtually 100% of fetuses. An epizootic (animal disease epidemic) of RVF is usually first indicated by a wave of unexplained abortions.

TRANSMISSION TO HUMANS:
*The vast majority of human infections result from direct or indirect contact with the blood or organs of infected animals. The virus can be transmitted to humans through the handling of animal tissue during slaughtering or butchering, assisting with animal births, conducting veterinary procedures, or from the disposal of carcasses or fetuses. Certain occupational groups such as herders, farmers, slaughterhouse workers and veterinarians are therefore at higher risk of infection. The virus infects humans through inoculation, for example via a wound from an infected knife or through contact with broken skin, or through inhalation of aerosols produced during the slaughter of infected animals. The aerosol mode of transmission has also led to infection in laboratory workers.

*There is some evidence that humans may also become infected with RVF by ingesting the unpasteurized or uncooked milk of infected animals.

*Human infections have also resulted from the bites of infected mosquitoes, most commonly the Aedes mosquito.

*Transmission of RVF virus by hematophagous (blood-feeding) flies is also possible.

*To date, no human-to-human transmission of RVF has been documented, and no transmission of RVF to health care workers has been reported when standard infection control precautions have been put in place.

*There has been no evidence of outbreaks of RVF in urban areas.

CLINICAL FEATURES IN HUMANS
Mild form of RVF in humans

*The incubation period (interval from infection to onset of symptoms) for RVF varies from two to six days.

*Those infected either experience no detectable symptoms or develop a mild form of the disease characterized by a feverish syndrome with sudden onset of flu-like fever, muscle pain, joint pain and headache.

*Some patients develop neck stiffness, sensitivity to light, loss of appetite and vomiting; in these patients the disease, in its early stages, may be mistaken for meningitis.

*The symptoms of RVF usually last from four to seven days, after which time the immune response becomes detectable with the appearance of antibodies and the virus gradually disappears from the blood.

Severe form of RVF in humans:

*While most human cases are relatively mild, a small percentage of patients develop a much more severe form of the disease. This usually appears as one or more of three distinct syndromes: ocular (eye) disease (0.5-2% of patients), meningoencephalitis (less than 1%) or haemorrhagic fever (less than 1%).

*Ocular form: In this form of the disease, the usual symptoms associated with the mild form of the disease are accompanied by retinal lesions. The onset of the lesions in the eyes is usually one to three weeks after appearance of the first symptoms. Patients usually report blurred or decreased vision. The disease may resolve itself with no lasting effects within 10 to 12 weeks. However, when the lesions occur in the macula, 50% of patients will experience a permanent loss of vision. Death in patients with only the ocular form of the disease is uncommon.

*Meningoencephalitis form: The onset of the meningoencephalitis form of the disease usually occurs one to four weeks after the first symptoms of RVF appear. Clinical features include intense headache, loss of memory, hallucinations, confusion, disorientation, vertigo, convulsions, lethargy and coma. Neurological complications can appear later (> 60 days). The death rate in patients who experience only this form of the disease is low, although residual neurological deficit, which may be severe, is common.

*Haemorrhagic fever form: The symptoms of this form of the disease appear two to four days after the onset of illness, and begin with evidence of severe liver impairment, such as jaundice. Subsequently signs of haemorrhage then appear such as vomiting blood, passing blood in the faeces, a purpuric rash or ecchymoses (caused by bleeding in the skin), bleeding from the nose or gums, menorrhagia and bleeding from venepuncture sites. The case-fatality ratio for patients developing the haemorrhagic form of the disease is high at approximately 50%. Death usually occurs three to six days after the onset of symptoms. The virus may be detectable in the blood for up to 10 days, in patients with the hemorrhagic icterus form of RVF.

The total case fatality rate has varied widely between different epidemics but, overall, has been less than 1% in those documented. Most fatalities occur in patients who develop the haemorrhagic icterus form.

DIAGNOSIS
Acute RVF can be diagnosed using several different methods. Serological tests such as enzyme-linked immunoassay (the “ELISA” or “EIA” methods) may confirm the presence of specific IgM antibodies to the virus. The virus itself may be detected in blood during the early phase of illness or in post-mortem tissue using a variety of techniques including virus propagation (in cell cultures or inoculated animals), antigen detection tests and RT-PCR.

TREATMENT AND VACCINE
*As most human cases of RVF are relatively mild and of short duration, no specific treatment is required for these patients. For the more severe cases, the predominant treatment is general supportive therapy.

*An inactivated vaccine has been developed for human use. However, this vaccine is not licensed and is not commercially available. It has been used experimentally to protect veterinary and laboratory personnel at high risk of exposure to RVF. Other candidate vaccines are under investigation.

RVF VIRUS IN ANIMAL HOSTS
*RVF is able to infect many species of animals causing severe disease in domesticated animals including cattle, sheep, camels and goats. Sheep appear to be more susceptible than cattle or camels.

*Age has also been shown to be a significant factor in the animal’s susceptibility to the severe form of the disease: over 90% of lambs infected with RVF die, whereas mortality among adult sheep can be as low as 10%.

*The rate of abortion among pregnant infected ewes is almost 100%. An outbreak of RVF in animals frequently manifests itself as a wave of unexplained abortions among livestock and may signal the start of an epidemic.

RVF VECTORS
*Several different species of mosquito are able to act as vectors for transmission of the RVF virus. The dominant vector species varies between different regions and different species can play different roles in sustaining the transmission of the virus.

*Among animals, the RVF virus is spread primarily by the bite of infected mosquitoes, mainly the Aedes species, which can acquire the virus from feeding on infected animals. The female mosquito is also capable of transmitting the virus directly to her offspring via eggs leading to new generations of infected mosquitoes hatching from eggs. This accounts for the continued presence of the RVF virus in enzootic foci and provides the virus with a sustainable mechanism of existence as the eggs of these mosquitoes can survive for several years in dry conditions. During periods of heavy rainfall, larval habitats frequently become flooded enabling the eggs to hatch and the mosquito population to rapidly increase, spreading the virus to the animals on which they feed.

*There is also a potential for epizootics and associated human epidemics to spread to areas that were previously unaffected. This has occurred when infected animals have introduced the virus into areas where vectors were present and is a particular concern. When uninfected Aedes and other species of mosquitoes feed on infected animals, a small outbreak can quickly be amplified through the transmission of the virus to other animals on which they subsequently feed.

PREVENTION AND CONTROL
Controlling RVF in animals

*Outbreaks of RVF in animals can be prevented by a sustained programme of animal vaccination. Both modified live attenuated virus and inactivated virus vaccines have been developed for veterinary use. Only one dose of the live vaccine is required to provide long-term immunity but the vaccine that is currently in use may result in spontaneous abortion if given to pregnant animals. The inactivated virus vaccine does not have this side effect, but multiple doses are required in order to provide protection which may prove problematic in endemic areas.

*Animal immunization must be implemented prior to an outbreak if an epizootic is to be prevented. Once an outbreak has occurred animal vaccination should NOT be implemented because there is a high risk of intensifying the outbreak. During mass animal vaccination campaigns, animal health workers may, inadvertently, transmit the virus through the use of multi-dose vials and the re-use of needles and syringes. If some of the animals in the herd are already infected and viraemic (although not yet displaying obvious signs of illness), the virus will be transmitted among the herd, and the outbreak will be amplified.

*Restricting or banning the movement of livestock may be effective in slowing the expansion of the virus from infected to uninfected areas.

*As outbreaks of RVF in animals precede human cases, the establishment of an active animal health surveillance system to detect new cases is essential in providing early warning for veterinary and human public health authorities.

Public health education and risk reduction:

*During an outbreak of RVF, close contact with animals, particularly with their body fluids, either directly or via aerosols, has been identified as the most significant risk factor for RVF virus infection. In the absence of specific treatment and an effective human vaccine, raising awareness of the risk factors of RVF infection as well as the protective measures individuals can take to prevent mosquito bites, is the only way to reduce human infection and deaths.

Public health messages for risk reduction should focus on:
*reducing the risk of animal-to-human transmission as a result of unsafe animal husbandry and slaughtering practices. Gloves and other appropriate protective clothing should be worn and care taken when handling sick animals or their tissues or when slaughtering animals.
*reducing the risk of animal-to-human transmission arising from the unsafe consumption of fresh blood, raw milk or animal tissue. In the epizootic regions, all animal products (blood, meat and milk) should be thoroughly cooked before eating.

*the importance of personal and community protection against mosquito bites through the use of impregnated mosquito nets, personal insect repellent if available, by wearing light coloured clothing (long-sleeved shirts and trousers) and by avoiding outdoor activity at peak biting times of the vector species.
Infection control in health care settings
*Although no human-to-human transmission of RVF has been demonstrated, there is still a theoretical risk of transmission of the virus from infected patients to healthcare workers through contact with infected blood or tissues. Healthcare workers caring for patients with suspected or confirmed RVF should implement Standard Precautions when handling specimens from patients.

*Standard Precautions define the work practices that are required to ensure a basic level of infection control. Standard Precautions are recommended in the care and treatment of all patients regardless of their perceived or confirmed infectious status. They cover the handling of blood (including dried blood), all other body fluids, secretions and excretions (excluding sweat), regardless of whether they contain visible blood, and contact with non-intact skin and mucous membranes. A WHO Aide–memoire on Standard Precautions in health care is available at: http://www.who.int/csr/resources/publications/standardprecautions/en/index.html

*As noted above, laboratory workers are also at risk. Samples taken from suspected human and animal cases of RVF for diagnosis should be handled by trained staff and processed in suitably equipped laboratories.

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Vector control
*Other ways in which to control the spread of RVF involve control of the vector and protection against their bites.
*Larviciding measures at mosquito breeding sites are the most effective form of vector control if breeding sites can be clearly identified and are limited in size and extent. During periods of flooding, however, the number and extent of breeding sites is usually too high for larviciding measures to be feasible.

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RVF FORESCASTING AND CLIMATIC MODELS
Forecasting can predict climatic conditions that are frequently associated with an increased risk of outbreaks, and may improve disease control. In Africa, Saudi Arabia and Yemen RVF outbreaks are closely associated with periods of above-average rainfall. The response of vegetation to increased levels of rainfall can be easily measured and monitored by Remote Sensing Satellite Imagery. In addition RVF outbreaks in East Africa are closely associated with the heavy rainfall that occurs during the warm phase of the El Niño/Southern Oscillation (ENSO) phenomenon.

These findings have enabled the successful development of forecasting models and early warning systems for RVF using satellite images and weather/climate forecasting data. Early warning systems, such as these, could be used to detect animal cases at an early stage of an outbreak enabling authorities to implement measures to avert impending epidemics.

Within the framework of the new International Health Regulations (2005), the forecasting and early detection of RVF outbreaks, together with a comprehensive assessment of the risk of diffusion to new areas, are essential to enable effective and timely control measures to be implemented.

Disclaimer: This information is not meant to be a substitute for professional medical advise or help. It is always best to consult with a Physician about serious health concerns. This information is in no way intended to diagnose or prescribe remedies.This is purely for educational purpose.

Resources:
http://en.wikipedia.org/wiki/Rift_Valley_fever
http://www.who.int/mediacentre/factsheets/fs207/en/

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Ailmemts & Remedies

Yellow Fever

TEM micrograph: Multiple yellow fever virions ...
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Definition:
Yellow fever (also called yellow jack, black vomit or sometimes American Plague) is an acute viral disease. It is an important cause of hemorrhagic illness in many African and South American countries despite existence of an effective vaccine. The yellow refers to the jaundice symptoms that affect some patients.It is a viral infection transmitted by mosquitoes.

Yellow fever is a viral hemorrhagic fever caused by the yellow fever virus. The yellow fever virus is a single-stranded enveloped virus that belongs to the flavivirus group. The disease can result in mild symptoms or severe illness and death (mortality rate 5-70%). Yellow fever derives its name from the yellowing of the skin and whites of the eyes (jaundice) that occur in some people infected with the virus. Jaundice is caused by the presence of bile pigment (bilirubin) in the bloodstream and results from damage to liver cells (hepatocytes) during severe infection.…click & see

The yellow fever virus infects mainly monkeys and humans: monkeys are the animal reservoir. Infection is transmitted from human to human, monkey to monkey, monkey to human, and human to monkey by daytime-biting mosquitos. Several species of Aedes and Haemoagogus mosquitos can serve as vectors, transmitting the virus during a blood meal.

Three types of transmission cycles exist for yellow fever: sylvatic (jungle), intermediate and urban. Although all three transmission cycles occur in Africa, only sylvatic and urban transmission cycles occur in South America.

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pictures

Sylvatic yellow fever (monkey to human)

* Occurs in monkeys infected by wild mosquitos in tropical rainforests

* Infected monkeys pass the virus to mosquitos during feeding
* Infected wild mosquitos bite humans entering the rainforest (accidental infection)

Intermediate yellow fever (monkey to human; human to monkey)
* Small-scale epidemics that occur in humid or semi-humid grasslands of Africa
* Separate villages experience simultaneous infections transmitted by semi-domestic mosquitos that infect both monkey and human hosts
* Most common type of outbreak in Africa

Urban yellow fever (human to human)

* Large epidemics occurring when the virus is introduced into high human population areas by migrants
* Domestic mosquitos of one species (Aedes aegypti) transmit the virus from person to person
* Monkeys are not involved in transmission
* Outbreaks spread from one source to cover a wide area

Yellow fever has been a source of several devastating epidemics. Yellow fever epidemics broke out in the 1700s in Italy, France, Spain, and England. 300,000 people are believed to have died from yellow fever in Spain during the 19th century. French soldiers were attacked by yellow fever during the 1802 Haitian Revolution; more than half of the army perished from the disease. Outbreaks followed by thousands of deaths occurred periodically in other Western Hemisphere locations until research, which included human volunteers (some of whom died), led to an understanding of the method of transmission to humans (primarily by mosquitos) and development of a vaccine and other preventive efforts in the early 20th century.

Despite the costly and sacrificial breakthrough research by Cuban physician Carlos Finlay, American physician Walter Reed, and many others over 100 years ago, unvaccinated populations in many developing nations in Africa and Central and South America continue to be at risk. As of 2001, the World Health Organization (WHO) estimates that yellow fever causes 200,000 illnesses and 30,000 deaths every year in unvaccinated populations.

Causes :-
Yellow fever is caused by a small virus that is spread by the bite of mosquitoes. This disease is common in South America and in sub-Saharan Africa.

……………You may click to see pictures of  mosquitoes  causing yellow fever.….

Anyone can get yellow fever, but the elderly have a higher risk of severe infection. If a person is bitten by an infected mosquito, symptoms usually develop 3 – 6 days later.

Yellow fever has three stages:
1.Early stage: Headache, muscle aches, fever, loss of appetite, vomiting, and jaundice are common. After approximately 3 – 4 days, often symptoms go away briefly (remission).

2.Period of remission: After 3 – 4 days, fever and other symptoms go away. Most people will recover at this stage, but others may move onto the third, most dangerous stage (intoxication stage) within 24 hours.

3.Period of intoxication: Multi-organ dysfunction occurs. This includes liver and kidney failure, bleeding disorders/hemorrhage, and brain dysfunction including delirium, seizures, coma, shock, and death.

Symptoms :-
*Arrhythmias, heart dysfunction
*Bleeding (may progress to hemorrhage)
*Coma
*Decreased urination
*Delirium
*Fever
*Headache
*Jaundice
*Muscle aches (myalgia)
*Red eyes, face, tongue
*Seizures
*Vomiting
*Vomiting blood

Although viral replication begins in cells at the site of the mosquito bite, symptoms of infection are not usually noted for a period of three to six days when the acute phase of infection presents. Acute yellow fever infection is characterized by high fever, muscle pain, backache, headache, shivers, loss of appetite, nausea and/or vomiting. Most people infected improve after three to four days.

However, within 24 hours of the disappearance of symptoms, up to 15% of those infected enter a toxic phase during which fever resumes, and the yellow fever virus quickly spreads to the kidneys, lymph nodes, spleen, bone marrow and liver. Liver invasion of one of the last stages to occur: as the liver is increasingly damaged, patients develop jaundice as bilirubin is released from damaged liver cells, experience abdominal pain and vomiting, and develop coagulopathies (inability of the blood to clot) characterized by bleeding from the mouth, nose, eyes and stomach, and presence of blood in vomit and stool. Up to 50% of people who enter the toxic phase die within two weeks of infection.

Diagnosis:-
Yellow fever may be difficult to diagnose, especially during the early stages, and may be confused with malaria, typhoid, other hemorrhagic fevers (dengue, Rift Valley, Venezuelan, Bolivian, Argentine, Lassa, Crimean-Congo, Marburg and Ebola), rickettsial infection, leptospirosis, viral hepatitis, other causes of liver failure and toxic hepatitis (e.g. carbon-tetrachloride poisoning).

Exams and Tests
A person with advanced yellow fever may show signs of liver failure, renal failure, and shock.

If you have symptoms of yellow fever, tell your doctor if you have traveled to areas where the disease is known to thrive. Blood tests can confirm the diagnosis.

Treatment :-

There is no specific treatment for yellow fever. Treatment for symptoms can include:

*Blood products for severe bleeding
*Dialysis for kidney failure
*Fluids through a vein (intravenous fluids)

The treatment for yellow fever is supportive: control of fever, fluids to treat dehydration, and intensive support related to organ damage.

The World Health Organization estimates 200,000 cases of yellow fever per year with approximately 30,000 deaths.

CLICK TO READ ..>: Early sign of yellow fever could lead to new treatment

Prognosis: :-

Yellow fever ranges in severity. Severe infections with internal bleeding and fever (hemorrhagic fever) are deadly in up to half of cases.

Historical reports have claimed a mortality rate of between 1 in 17 (5.8%) and 1 in 3 (33%). CDC has claimed that case-fatality rates from severe disease range from 15% to more than 50%. The WHO factsheet on yellow fever, updated in 2001, states that 15% of patients enter a “toxic phase” and that half of that number die within ten to fourteen days, with the other half recovering

Possible Complications :-

*Coma
*Death
*Disseminated intravascular coagulation (DIC)
*Kidney failure
*Liver failure
*Parotitis
*Secondary bacterial infections
*Shock

Prevention :-

If you will be traveling to an area where yellow fever is common:

*Sleep in screened housing
*Use mosquito repellents
*Wear clothing that fully covers your body
*There is an effective vaccine against yellow fever. Ask your doctor at least 10 – 14 days before traveling if you should be *vaccinated against yellow fever.

In 1937, Max Theiler, working at the Rockefeller Foundation, developed a safe and highly efficacious vaccine for yellow fever that gives a ten-year or more immunity from the virus. The vaccine consists of a live, but attenuated, virus called 17D. The 17D vaccine has been used commercially since the 1950s. The mechanisms of attenuation and immunogenicity for the 17D strain are not known. However, this vaccine is very safe, with few adverse reactions having been reported and millions of doses administered, and highly effective with over 90% of vaccinees developing a measurable immune response after the first dose.

click to see the picture

Although the vaccine is considered safe, there are risks involved. The majority of adverse reactions to the 17D vaccine result from allergic reaction to the eggs in which the vaccine is grown. Persons with a known egg allergy should discuss this with their physician prior to vaccination. In addition, there is a small risk of neurologic disease and encephalitis, particularly in individuals with compromised immune systems and very young children. The 17D vaccine is contraindicated in infants, pregnant women, and anyone with a diminished immune capacity, including those taking immunosuppressant drugs.

According to the travel clinic at the University of Utah Hospital, the vaccine presents an increased risk of adverse reaction in adults aged 60 and older, with the risk increasing again after age 65, and again after age 70. The reaction is capable of producing multiple organ failure and should be evaluated carefully by a qualified health professional before being administered to the elderly.

Finally, there is a very small risk of more severe yellow fever-like disease associated with the vaccine. This reaction occurs in 1~3 vaccinees per million doses administered. This reaction, called YEL-AVD, causes a fairly severe disease closely resembling yellow fever caused by virulent strains of the virus. The risk factor/s for YEL-AVD are not known, although it has been suggested that it may be genetic. The 2`-5` oligoadenylate synthetase (OAS) component of the innate immune response has been shown to be particularly important in protection from Flavivirus infection. In at least one case of YEL-AVD, the patient was found to have an allelic mutation in a single nucleotide polymorphism (SNP) of the OAS gene. People most at risk of contracting the virus should be vaccinated. Woodcutters working in tropical areas should be particularly targeted for vaccination. Insecticides, protective clothing, and screening of houses are helpful, but not always sufficient for mosquito control; people should always use an insecticide spray while in certain areas. In affected areas, mosquito control methods have proven effective in decreasing the number of cases.

Recent studies have noted the increase in the number of areas affected by a number of mosquito-borne viral infections and have called for further research and funding for vaccines

Current research:-
In the hamster model of yellow fever, early administration of the antiviral ribavirin is an effective early treatment of many pathological features of the disease. Ribavirin treatment during the first five days after virus infection improved survival rates, reduced tissue damage in target organs (liver and spleen), prevented hepatocellular steatosis, and normalized alanine aminotransferase (a liver damage marker) levels. The results of this study suggest that ribavirin may be effective in the early treatment of yellow fever, and that its mechanism of action in reducing liver pathology in yellow fever virus infection may be similar to that observed with ribavirin in the treatment of hepatitis C, a virus related to yellow fever. Because ribavirin had failed to improve survival in a virulent primate (rhesus) model of yellow fever infection, it had been previously discounted as a possible therapy.

In 2007, the World Community Grid launched a project whereby computer modelling of the yellow fever virus (and related viruses), thousands of small molecules are screened for their potential anti-viral properties in fighting yellow fever. This is the first project to utilize computer simulations in seeking out medicines to directly attack the virus once a person is infected. This is a distributed process project similar to SETI@Home where the general public downloads the World Community Grid agent and the program (along with thousands of other users) screens thousands of molecules while their computer would be otherwise idle. If the user needs to use the computer the program sleeps. There are several different projects running, including a similar one screening for anti-AIDS drugs. The project covering yellow fever is called “Discovering Dengue Drugs – Together.” The software and information about the project can be found at: World Community Grid web site

Disclaimer: This information is not meant to be a substitute for professional medical advise or help. It is always best to consult with a Physician about serious health concerns. This information is in no way intended to diagnose or prescribe remedies.This is purely for educational purpose.
Resources:
http://en.wikipedia.org/wiki/Yellow_fever
http://www.nlm.nih.gov/medlineplus/ency/article/001365.htm
http://microbiology.suite101.com/article.cfm/yellow_fever

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News on Health & Science

Biting Back At Malaria With Mosquitoes

CLICK & SEEAn American scientist is leading an international team of researchers using an army of blood-sucking mosquitoes to produce a potentially potent vaccine against malaria.

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Stephen Hoffman, 58, founded Sanaria Inc, a biotech firm solely dedicated to the production of a vaccine against malaria.
Hoffman officially opened a manufacturing facility on Friday in the Washington suburb of Rockville, where he said he aims to produce 75 to 100 million doses a year. “The opening of this facility is an important step in the process to develop a whole-parasite malaria vaccine,” he said. The scientist said he was optimistic the vaccine could be tested in clinical trials by late 2008.

His goal, which has received US government support, was given a major boost in late 2006 when the Bill and Melinda Gates Foundation donated 29.3 million dollars through the PATH Malaria Vaccine Initiative, Hoffman said. Hoffman knows the debilitating effects of malaria all too well.

In the 1980s, when he was director of the US Navy’s malaria research programme, he was so confident in a new vaccine that he reportedly let himself be bitten by mosquitoes carrying Plasmodium falciparum, the malaria parasite responsible for over 95% of severe malarial illnesses and deaths worldwide.

Sure enough, he came down with the symptoms. The vaccine did not work. Despite that failure, the researcher has taken the same approach and hopes that a vaccine can be mass produced and maintain its potency. His firm is “turning the mosquitoes into the production factories for the vaccine,” he said, adding that each mosquito can produce two doses of the vaccine. “We have a long way to go before we’ll be able to license and deploy an effective vaccine to control and eventually eradicate malaria from the world, but most importantly to prevent the 3,000 deaths that will occur today among children and one million in a year.”

Source:The Times Of India

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Herbs & Plants

Indian Neem Plant (Azadirachta indica)

Botanical Name: Azadirachta indica
Family: Meliaceae (mahogany)
Kingdom: Plantae
Order: Sapindales
Genus: Azadirachta
Species: A. indica

Other common names: Pride of India, Azadirachta, Nim, Margosa, Holy Tree, Indian Lilac Tree, Bead Tree
Vernacular names:
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Names for this plant in various languages include;
Arabic – Neeb, Azad-darakhul-hind, Shajarat Alnnim
Assamese – Neem
Bengali – Nim
English – Margosa, Neem Tree
French – Azadirac de l’Inde, margosier, margousier
German – Indischer zedrach, Grossblaettiger zedrach
Gujarati – Dhanujhada, Limbda
Hausa – Darbejiya, Dogonyaro, Bedi
Hindi – Neem
Kannada – Bevu
Kiswahili – Muarubaini
Khmer – Sdau
Malay – Mambu
Malayalam – Aryaveppu
Manipuri – Neem
Marathi – Kadunimba
Myanmar – Burma- Tamar
Nepal – Neem
Nigerian – Dongoyaro
Persian – Azad Darakth e hind, neeb, nib
Portuguese – Nimbo, Margosa, Amargoseira
Punjabi – Nimmh
Sanskrit – Arishta, Pakvakrita, Nimbaka
Sinhala – Kohomba
Sindhi – Nimm
Somali – Geed Hindi
Tamil – Veppai , Sengumaru
Telugu – Vepa
Thai – Sadao
tulu-besappu
Urdu – Neem

Habitat: Azadirachta indica  is native to India and the Indian subcontinent including Nepal, Pakistan, Bangladesh and Sri Lanka. It is typically grown in tropical and semi-tropical regions. Neem trees now also grow in islands located in the southern part of Iran. Its fruits and seeds are the source of neem oil.

Description:
Neem is a fast-growing tree that can reach a height of 15–20 metres (49–66 ft), and rarely 35–40 metres (115–131 ft). It is evergreen, but in severe drought it may shed most or nearly all of its leaves. The branches are wide and spreading. The fairly dense crown is roundish and may reach a diameter of 15–20 metres (49–66 ft) in old, free-standing specimens. The neem tree is very similar in appearance to its relative, the Chinaberry (Melia azedarach).

The opposite, pinnate leaves are 20–40 centimetres (7.9–15.7 in) long, with 20 to 31 medium to dark green leaflets about 3–8 centimetres (1.2–3.1 in) long. The terminal leaflet is often missing. The petioles are short.

The (white and fragrant) flowers are arranged in more-or-less drooping axillary panicles which are up to 25 centimetres (9.8 in) long. The inflorescences, which branch up to the third degree, bear from 150 to 250 flowers. An individual flower is 5–6 millimetres (0.20–0.24 in) long and 8–11 millimetres (0.31–0.43 in) wide. Protandrous, bisexual flowers and male flowers exist on the same individual tree.

The fruit is a smooth (glabrous), olive-like drupe which varies in shape from elongate oval to nearly roundish, and when ripe is 1.4–2.8 centimetres (0.55–1.10 in) by 1.0–1.5 centimetres (0.39–0.59 in). The fruit skin (exocarp) is thin and the bitter-sweet pulp (mesocarp) is yellowish-white and very fibrous. The mesocarp is 0.3–0.5 centimetres (0.12–0.20 in) thick. The white, hard inner shell (endocarp) of the fruit encloses one, rarely two or three, elongated seeds (kernels) having a brown seed coat.

 

CLICK TO SEE THE PICTURES…..(01).....(1)……….(2)………(3)……….(4).…..(5).....(6)...

Commercial plantations of the trees are not considered profitable. Around 50,000 neem trees have been planted near Mecca to provide shelter for the pilgrims.

Warning: The neem tree is very much lookalike to the Chinaberry, whose fruits (and everything else) are extremely poisonous.

Medicinal and other uses:

Neem Leaf is said to be India’s best-kept secret, and for thousands of years this “Pride of India”

has treated more than one hundred health problems! It is said to be one of the most important detoxicants in Ayurvedic medicine and is also believed to be a potent antiviral, antifungal, antibacterial and parasiticide that combats infections of all kinds. In addition, Neem is used to facilitate digestion, support heart health, improve the urinary tract and treat fevers and pain. Important, new research claims that Neem will help diabetics and combat invasive disease.

Neem Leaf is a bitter tonic herb that nourishes and strengthens the digestive tract and is excellent for digestive disorders. Because it is believed to work wonders for the gastrointestinal tract (the passage along which food passes for digestion, including esophagus, stomach, duodenum, liver, pancreas, gallbladder, small and large intestines), Neem is often taken to correct problems of the stomach and bowels and is effective in easing nausea, indigestion, gastritis, intestinal distress, hyperacidity, and peptic and duodenal ulcers. It also appears to reduce gastric secretions and aids in eliminating toxins and harmful bacteria from the system, thereby reducing stomach discomfort.

In the treatment of constipation, Neem Leaf is thought to be an effective purgative, especially in larger doses, but because it is also a soothing demulcent, it is not a harsh laxative, and its use is thought to regulate bowel function. It has also been used as an anthelmintic, which destroys and expels intestinal worms, perhaps because of its effective laxative and parasiticidal properties.

Neem Leaf is thought to support heart health in several ways. Recent studies have shown that the leaf extract, nimbidin, significantly lowers serum cholesterol levels, which helps to reduce blood clots. Nimbidin also causes blood vessels to dilate and may be responsible for lowering blood pressure and improving blood circulation. These actions are thought to reduce the risk for arteriosclerosis, stroke and heart attack. Moreover, it is also thought to slow rapid heartbeat and inhibit irregularities of the rhythms of the heart (arrhythmia).

Neem Leaf is said to improve many urinary tract disorders, especially burning urination. The leaf extract, sodium nimbidinate, acts as a diuretic, promoting the flow of urine, and this action helps to relieve phosphaturia (excess phosphates in the urine) and albuminuria (escess albumin in the urine), which can be caused by chronic congestion of the kidneys. The increased urine helps to flush the kidneys and further cleanse toxins from the system.

The tannin in Neem Leaf acts as an astringent, and as such, it has been used to remedy diarrhea and dysentery.

Neem Leaf is said to be one of the finest detoxicants available that clears pollutants from the body. The herb’s antiseptic qualities are said to cleanse the blood of harmful bacteria that cause infections. Moreover, cleaner blood is invaluable for improving skin conditions, and Neem Leaf has been famous for its beneficial effects in cases of skin diseases and problems, including eczema, psoriasis, septic sores, infected burns, boils, acne and scrofula.

Supporting Neem’s traditional role as an antibacterial (twig) toothbrush, modern studies confirm its important role in total oral hygiene. Neem’s antimicrobial and antiseptic properties are effective in reducing plaque, caries, gingival scores and pathogenic (disease causing) bacteria in the mouth. A mouthwash prepared from Neem extract was found to inhibit the growth of Streptococcus mutans,

an oral pathogen (bacteria) responsible for dental caries and was effective in reversing mouth ulcers (incipient carious lesions).

Recent research is being conducted into the use of Neem Leaf for diabetes. A number of insulin-dependent diabetics were able to reduce their insulin considerably when treated with Neem Leaf extract and Neem oil. The general impression is that Neem may enhance insulin receptor sensitivity and may work well on Type II diabetics.

Neem Leaf is a virtual living pharmacy and is a powerful antibacterial and antifungal. Its quercetin content (a polyphenolic flavonoid) helps to combat infections and certain fungi. Neem is believed to destroy the fourteen most common fungi that infect the human body, such as athlete’s foot, nail fungus, intestinal tract fungi and a fungus that is part of the normal mucous flora that may get out of control and lead to lesions in the mouth, vagina, skin, hands and lungs.

As an antiviral, Neem Leaf has been used to combat smallpox, chicken pox, and recent tests have shown that it may be effective against herpes virus and the viral DNA polymerase of hepatitis B virus.

Neem has been used in Ayurvedic medicine to treat malarial fevers, and recent experiments have shown that one of the Neem’s components, gedunin, is as effective as quinine against malaria. It is also used to control trypanosomiasis (African sleeping sickness or Chagas’ disease), caused by a parasite that lives inside nerve and muscle cells. Neem is also considered effective in reducing fever, relieving pain and reducing inflammation.

Neem Leaf is said to be an expectorant that loosens and expels phlegm and congestion from the respiratory system and has been used to relieve dry cough, nasal congestion, bronchitis, laryngitis, pharyngitis, tuberculosis, pleurisy and other respiratory disorders.

Neem has been used effectively as a contraceptive since the first century B.C., when an eminent Ayurvedic physician wrote of its use for this purpose. It is a highly potent antibacterial, spermicidal, parasiticide, antifungal and antiviral, and in cases of sexual contact, current studies claim that it may help to prevent AIDS, gonorrhea, trichomonas, chlamydia and other sexually transmitted conditions. Whether ingested or used topically in the vagina, the leaves and oil have been effective in killing human spermatozoa. Many women in Madagascar chew Neem leaves every day, which is believed to prevent pregnancies, and in cases of unwanted pregnancies, it is thought to be capable of inducing a miscarriage (it is a uterine stimulant that has also been used to stimulate suppressed menstruation). Neem Leaves have been used as a vaginal douche to heal wounds caused during delivery and disinfect the vaginal passage.

When used externally, Neem Leaf is used as an eyewash for the treatment of night blindness, in shampoos for hair loss and premature graying. Used topically, its antiseptic, insecticidal and antiviral properties are believed efficacious against septic sores, warts, infected burns, ringworm, lice, boils, ulcers, indolent ulcers, glandular swellings, wounds, smallpox, syphilitic sores and eczema. Its anti-inflammatory qualities will also relieve painful joints and muscles.
Neem Leaf is said to be India’s best-kept secret, and for thousands of years this “Pride of India” has treated more than one hundred health problems! It is said to be one of the most important detoxicants in Ayurvedic medicine and is also believed to be a potent antiviral, antifungal, antibacterial and parasiticide that combats infections of all kinds. In addition, Neem is used to facilitate digestion, support heart health, improve the urinary tract and treat fevers and pain. Important, new research claims that Neem will help diabetics and combat invasive disease.
Neem is perhaps the most useful traditional medical plant, mostly available in India.Each part of the neem tree has tremendus medical properity and is thus commercially exploitable.It is considered as a most valuable sourse of unique biological product for the development of different kinds of medicines against various diseases and also for the industrial products.Its phermacological value is vast.

Various parts of neem tree have been used as a tradtional Ayurbedic medicine in India from time immemorial. It’s leaf,root,flower and fruit togather cure blood morbidity,bilary afflictions,itching,skin ulsers,burning sensations. We can have various use of neem in our day to day life:-
 * Mix pure, dried neem leaf powder with vaseline in the ratio of 1:5. This combination can be used to repel insects including mosquitoes. It can also be used to treat skin disorders, minor cuts, burns, wounds, etc.

* Boil neem leaves with water and add to bath water along with rose water to cure itching, excessive perspiration, etc.

* Boil 10 freshly cleaned neem leaves along with cotton in a litre of water for approximately 10 minutes. Keep it aside to cool. Use this to rinse your eyes in case of conjunctivitis, itching, etc.

* Use pure neem oil mixed with coconut and sandalwood oil for treating hairfall, premature greying, lice, dandruff and scalp infections.

* To treat a sore throat without antibiotics, gargle with neem leaf water to which honey is added.

* For acne, pimples and skin infections, apply pure neem leaf powder mixed with water to the affected area.

* In case of sinusitis, use pure neem oil as nasal drops. Use 1-2 drops in the morning and evening.

* Boil 40-50 neem leaves in 250 ml for 20 minutes. Cool, strain, bottle, refrigerate and store to use as an astringent.

* Chewing four to five neem leaves regularly helps in cases of hyperacidity and diabetes. It also purifies blood.

* Neem oil has anti-fungal properties. Putting two drops of neem oil in the ear once daily, at bedtime, helps to cure fungal infection of the ear.

* For jaundice, juice of neem leaves (15-30 ml) and half the quantity of honey taken on an empty stomach for seven days is recommended.

* Prevent breeding of mosquitoes by adding crushed neem seeds and neem oil to all breeding areas. Neem products ensure complete inhibition of egg laying for seven days.

* Add 30 ml of neem oil to one litre of water. Mix well. Add one ml of Teepol and spray immediately for plant protection.

* To ward off mosquitoes, add five to 10 per cent neem oil to any oil and light as a candle.

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Other uses:
Construction: The juice of this plant is a potent ingredent for a mixture of wall plaster, according to the Samar??ga?a S?tradh?ra, which is a Sanskrit treatise dealing with ?ilpa??stra (Hindu science of art and construction).

Neem oil is used for preparing cosmetics such as soap, shampoo, balms and creams as well as toothpaste.

Toothbrush: Traditionally, slender neem twigs (called datun) are first chewed as a toothbrush and then split as a tongue cleaner. This practice has been in use in India, Africa, and the Middle East for centuries. Many of India’s 80% rural population still start their day with the chewing stick, while in urban areas neem toothpaste is preferred. Neem twigs are still collected and sold in markets for this use, and in rural India one often sees youngsters in the streets chewing on neem twigs. It has been found to be as effective as a toothbrush in reducing plaque and gingival inflammation.

Tree: Besides its use in traditional Indian medicine, the neem tree is of great importance for its anti-desertification properties and possibly as a good carbon dioxide sink.

Neem gum is used as a bulking agent and for the preparation of special purpose foods.

Neem blossoms are used in Andhra Pradesh, Tamil Nadu and Karnataka to prepare Ugadi pachhadi. A mixture of neem flowers and jaggery (or unrefined brown sugar) is prepared and offered to friends and relatives, symbolic of sweet and bitter events in the upcoming new year, Ugadi. “Bevina hoovina gojju” (a type of curry prepared with neem blossoms) is common in Karnataka throughout the year. Dried blossoms are used when fresh blossoms are not available. In Tamil Nadu, a rasam (veppam poo rasam) made with neem blossoms is a culinary specialty.

Cosmetics : Neem is perceived in India as a beauty aid. Powdered leaves are a major component of at least one widely used facial cream. Purified neem oil is also used in nail polish and other cosmetics.

Bird repellent: Neem leaf boiled in water can be used as a very cost-effective bird repellent, especially for sparrows.

Lubricant : Neem oil is non-drying and it resists degradation better than most vegetable oils. In rural India, it is commonly used to grease cart wheels.

Fertilizer : Neem has demonstrated considerable potential as a fertilizer. Neem cake is widely used to fertilize cash crops, particularly sugarcane and vegetables.

Plant protectant : Ploughed into the soil, it protects plant roots from nematodes and white ants, probably as it contains the residual limonoids.
In Karnataka, people grow the tree mainly for its green leaves and twigs, which they puddle into flooded rice fields before the rice seedlings are transplanted.

Resin : An exudate can be tapped from the trunk by wounding the bark. This high protein material is not a substitute for polysaccharide gum, such as gum arabic. It may, however, have a potential as a food additive, and it is widely used in South Asia as “Neem glue”.

Bark : Neem bark contains 14% tannin, an amount similar to that in conventional tannin-yielding trees (such as Acacia decurrens). Moreover, it yields a strong, coarse fibre commonly woven into ropes in the villages of India.

Honey : In parts of Asia neem honey commands premium prices, and people promote apiculture by planting neem trees.

Soap : 80% of India’s supply of neem oil is now used by neem oil soap manufacturers. Although much of it goes to small-scale speciality soaps, often using cold-pressed oil, large-scale producers also use it, mainly because it is cheap. Additionally it is antibacterial and antifungal, soothing and moisturising. It can be made with up to 40% neem oil. Generally, the crude oil is used to produce coarse laundry soaps.

Against pox viruses : In India, people who are affected with pox viruses are generally made to lie in bed made of neem leaves and branches. This prevents the spreading of pox virus to others and has been in practice since early centuries.
Known Hazards: Neem oil can cause some forms of toxic encephalopathy and ophthalmopathy if consumed in large quantities

Disclaimer:
The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider.

Resources:

http://en.wikipedia.org/wiki/Neem

http://www.herbalextractsplus.com/neem-leaf.cfm?gclid=CJ_HpOPxg40CFQI5PwodGRGcoQ

http://www.mansha-enterprises.com/organic-products.html

https://en.wikipedia.org/wiki/Azadirachta_indica

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