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Some Fruit Juices Lower Drug Effect

Grapefruit, orange and apple juices can harm the body’s ability to absorb certain medications and make the drugs less effective, said a study.

The research showed that these juices can decrease the effectiveness of certain drugs used to treat heart disease, cancer, organ-transplant rejection and infection, “potentially wiping out their beneficial effects”, it said.

David Bailey, a professor of clinical pharmacology with the University of Western Ontario and leader of the study, was the first researcher to identify grapefruit juice‘s potential to increase the absorption of certain drugs two decades ago, possibly turning some doses toxic.

The new findings came as part of his continuing research on the subject, and were presented at the 236th annual meeting of the American Chemical Society on Philadelphia, Pennsylvania.

“Recently, we discovered that grapefruit and these other fruit juices substantially decrease the oral absorption of certain drugs undergoing intestinal uptake transport,” said Bailey. “The concern is loss of benefit of medications essential for the treatment of serious medical conditions.”

Healthy volunteers took fexofenadine, an antihistamine used to fight allergies, along with either a glass of grapefruit juice, a glass of water with naringin (which gives the bitter taste to grapefruit juice), or plain water.

Those who drank the grapefruit juice absorbed only half the amount of fexofenadine, compared to those who drank plain water.

Researchers said the water with naringin served to block “a key drug uptake transporter, called OATP1A2, involved in shuttling drugs from the small intestine to the bloodstream”.

Among the drugs affected by consumption of grapefruit, orange and apple juices are: etoposide, an anticancer agent; beta blockers used to treat high blood pressure and prevent heart attacks; and certain antibiotics (ciprofloxacin, levofloxacin, itraconazole).

The drug-lowering interaction also affected cyclosporine, a drug taken to prevent rejection of transplanted organs, and more drugs were expected to be added to the list as the research continued.

Sources: The Times Of India

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Beauty of the Beetroot

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Scientists have discovered that beetroot has a remarkable effect on lowering blood pressure. Maria Fitzpatrick tries a medically approved new juice...

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Have you ever considered swapping your morning glass of fresh orange for freshly squeezed beetroot? Thought not – but in light of a remarkable discovery, it may be worth downing the inky, purple-red stuff with your cornflakes. And, thanks to the launch this month of a scrumptious new juice, getting your daily dose won’t require a pinch of the nose or scrubbing stubborn, deep purple stains off your chopping board.

Earlier this year, scientists at Barts and the London School of Medicine found that beetroot juice can have as great an effect on blood pressure as conventional drugs.

Led by Professor Amrita Ahluwalia of the William Harvey Research Institute – the renowned pharmacology centre that discovered how aspirin can prevent heart attacks and strokes – the research team found that just three hours after drinking 500ml of the juice (the equivalent of eating five medium-sized beetroots) there was a significant decrease in volunteers’ blood pressure. The remarkable effects were still noticeable 24 hours later.

That such an inexpensive and bounteous vegetable may lower blood pressure makes beetroot worthy of its new-found status as the first “super-root”. However, the woody consistency, off-putting earthy aroma and overly sweet taste (delete as applicable), of its raw juice have long prevented more of us taking a glug – which is a shame, given that one in three adults in the UK now suffers from hypertension and could benefit from a regular 250ml dose, the equivalent of an average glass.

According to the Blood Pressure Association, a third of sufferers don’t even realise they have the condition, which results in an estimated 350 “preventable” strokes or heart attacks every day.
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So how does beetroot work in the body? Like other superfoods, it has antioxidants in abundance, and is rich in iron, boron and folic acid. Betanene, which gives it its deep colour, is even more potent an antioxidant than polyphenols, the plant chemicals thought to be a key reason for people whose diets are rich in leafy vegetables having lower blood pressure.

But, says Professor Ben Benjamin, a consultant in Acute Medicine at the Peninsula Medical School in Plymouth and member of the research team, it is beetroot’s capacity to absorb and store exceptionally high levels of nitrate that earns it the super-root title. Nitrates are nutrients found in soil which all plants need to build protein, and which the body harnesses in its battle against blood pressure.

“When nitrate is present in high concentration in saliva, bacteria on the tongue converts it into a more reactive chemical, nitrite,” Prof Benjamin explains. “When the nitrite is swallowed, it is easily converted into nitric oxide, a chemical which is continually produced by our blood vessels to make them relax and hence keep blood pressure low. So dramatically increasing the levels of nitrate with beetroot juice increases this effect.”

Along with its anti-hypertensive effects, the study also found that the high levels of nitrates in beetroot juice work like aspirin does to prevent blood clots, and help to protect the lining of the blood vessels.

So encouraged were researchers by the magnitude of the blood pressure effect that they approached a Suffolk-based natural drinks company to produce a bottled beetroot juice that would make it easy for people to introduce the root into their diet.

The resulting juice, HeartBeet, is certainly palatable, and definitely good for you. A “no bits” blend of crushed organic roots, with a touch of apple juice (10 per cent) to balance out the taste, it is now on sale in selected Holland & Barrett stores. Unlike other juices already available, seven per cent of its proceeds will go directly back into funding cardiovascular research.

It’s rare for the medical community to put its weight so boldly behind the power of nature over pharmacology. According to Prof Benjamin, it is testament to the importance of the findings, which he believes could lead the way to proving that high blood pressure can be treated by altering diet alone, and with fewer – if any – conventional drugs.

“Currently, treatment for high blood pressure involves a cocktail of aspirin, statins, beta blockers, and angiotensin converting enzyme (ACE) inhibitors. Many people really don’t like taking all the tablets, especially since they often don’t feel unwell, and the treatment is essentially lifelong.”

One patient with high blood pressure, 60-year-old David Kelsall from Stoke-on-Trent, is already reaping the rewards of drinking a glass of beetroot juice a day. “I discovered that my blood pressure was higher than normal when my doctor was testing for something else,” he says. “It was 165/90mmHg – not life-threateningly serious, but none the less I was anxious to do something about it.”

Before committing to medication, he decided to give beetroot juice a try. “I drank three bottles of liquidised beetroot a week. Less than four weeks after the first test, I had my blood pressure taken again, and it had already levelled out to 150/90mmHg.” (A normal blood pressure reading would be in the range of 120/80mmHg.) “Now, a few months later, it is under control and normal. I am still drinking the juice, and I’m going to continue doing so. It may not help everyone, but it’s helped me.”

A growing body of research around the world suggests that the crucial nitrates in beetroot may also contribute to protecting us against other diseases, including infections and stomach ulcers – yet more reason to drink up. Having established a connection with blood pressure, scientists are now assessing just how much – or, rather, how little – of the juice is required for it to be effective.

If nothing else, beetroot’s health credentials give us all a reason to be smug: for once, the British country garden has come up with a foodstuff that trumps those in the Mediterranean “wonder diet”. And right now is the perfect time to grow your own. Beetroot seeds won’t germinate in temperatures below 7°C, or when there’s any inkling of ground frost, so early- to mid-summer is ideal to start planting. It can take as little as 10 weeks for a crop to mature, so you could be serving beetroot juice at your final summer barbecue of the year. We should all drink to that!
# HeartBeet organic beetroot juice (£1.49 for 25cl) is available from major Holland & Barrett stores (0870 606 6605, www.hollandandbarrett.com). For more details, call 01473 890111 or visit www.heartbeet.info

Sources: Telegraph.co.uk

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Six Healthy-Sounding Foods That Really Aren’t

Many foods have been heavily promoted as being healthy. But not all of them are. Here are some foods which are far less “good for you” than most people believe.

Energy bars…………..

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Energy bars usually contain protein and fiber, but they may also be loaded with calories. That’s fine if you occasionally make one a meal, but most people eat them as snacks.

Granola

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Granola sounds healthy. But it’s often high in fat, sugar and calories. Don’t be fooled by a seemingly low calorie count; the portion sizes on the label are usually tiny.

Salad Toppings

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The pecans and Gorgonzola cheese on Panera Bread’s Fuji Apple Chicken Salad propel it into double-cheeseburger territory. Before ordering a salad, check its nutrition information.

Smoothies

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Added sugars can make some smoothies the equivalent of drinking fruit pie filling. The smallest serving of Jamba Juice’s Orange Dream Machine has 340 calories and an astonishing 69 grams of sugars.

Sushi Rolls

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Sushi rolls vary, and the fried bits and mayonnaise in some can really jack up the calories.

Yogurts

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The “fruit” in yogurt is really jam (that is to say, mostly sugar).

Sources: Shine from Yahoo May 22, 2008

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Juice ‘Prevents Clogged Arteries’

Juices made from apples or purple grapes – and the fruit themselves – protect against developing clogged arteries, a study suggests.

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Juice made from purple grapes had the most beneficial effect

Researchers fed hamsters the fruit and juice or water, plus a fatty diet.

The animals who were fed grape juice had the lowest risk of developing artery problems, Molecular Nutrition and Food Research reports.

The University of Montpellier team said the juice’s benefits came from its high levels of phenols – an antioxidant.

Antioxidants in various foods have been regularly cited as being beneficial to heart health.

The French team looked at how juicing affected the phenol content of fruit – because most studies look at raw fruit.

Four glasses a day

They then looked at how being fed various kinds of fruit affected the hamsters’ risk of atherosclerosis – the build-up of fatty plaque deposits in the arteries that can lead to heart attacks or strokes.

The amount of fruit the hamsters consumed was equivalent to three apples or three bunches of grapes daily for a human.

Hamsters given juice drank the equivalent of four glasses daily for a person weighing 70 kilograms (154 pounds).

The apples and grapes had about the same phenol content, while the purple grape juice had 2.5 times more phenols than apple juice.

Compared with animals given water, those given fruit or fruit juice had lower cholesterol levels, less oxidative stress, and less fat accumulation in their aorta, the main vessel supplying oxygenated blood to the body.

Purple grape juice had the strongest effect, followed by purple grapes, apple juice and apples.

The researchers say their findings suggest the amount of phenols contained in a food have a direct effect on its antioxidant properties.

Other antioxidant compounds in the fruits, such as vitamin C and carotenoids, could also contribute to their effects, they added.

The team, led by Kelly Decorde, said their findings “provide encouragement that fruit and fruit juices may have a significant clinical and public health relevance.”

A British nutritionist said: “High levels of antioxidants are recognised as being good for you.”

You may also click to see:->Beetroot ‘May Cut Blood Pressure’

Apple juice ‘may prevent asthma’
Berry juice may be a heart tonic

Molecular Nutrition and Food Research April ’08

Sources: BBC NEWS:MAY 16, ’08

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Healthy Tips

Fresh vs Frozen Vegetables

Are we giving up nutrition for convenience? The answer may surprise you.:
Americans typically eat only one-third of the recommended daily intake (three servings instead of nine) of fruits and vegetables, so if you are in a bind, a vegetable in any form is better than no vegetable at all.

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And as winter approaches, fresh produce is limited  or expensive  in much of the country, which forces many of us to turn to canned or frozen options. While canned vegetables tend to lose a lot of nutrients during the preservation process (notable exceptions include tomatoes and pumpkin), frozen vegetables may be even more healthful than some of the fresh produce sold in supermarkets, says Gene Lester, Ph.D., a plant physiologist at the USDA Agricultural Research Center in Weslaco, Texas. Why? Fruits and vegetables chosen for freezing tend to be processed at their peak ripeness, a time when  as a general rule  they are most nutrient-packed.

While the first step of freezing vegetables  blanching them in hot water or steam to kill bacteria and arrest the action of food-degrading enzyme   causes some water-soluble nutrients like vitamin C and the B vitamins to break down or leach out, the subsequent flash-freeze locks the vegetables in a relatively nutrient-rich state.

On the other hand, fruits and vegetables destined to be shipped to the fresh-produce aisles around the country typically are picked before they are ripe, which gives them less time to develop a full spectrum of vitamins and minerals. Outward signs of ripening may still occur, but these vegetables will never have the same nutritive value as if they had been allowed to fully ripen on the vine. In addition, during the long haul from farm to fork, fresh fruits and vegetables are exposed to lots of heat and light, which degrade some nutrients, especially delicate vitamins like C and the B vitamin thiamin.

Bottom line:
When vegetables are in-season, buy them fresh and ripe. “Off-season,” frozen vegetables will give you a high concentration of nutrients. Choose packages marked with a USDA “U.S. Fancy” shield, which designates produce of the best size, shape and color; vegetables of this standard also tend to be more nutrient-rich than the lower grades “U.S. No. 1” or “U.S. No. 2.” Eat them soon after purchase: over many months, nutrients in frozen vegetables do inevitably degrade. Finally, steam or microwave rather than boil your produce to minimize the loss of water-soluble vitamins.

Click to learn more:

Will These Foods Make You Smarter?

Do You Know Where Your Food Comes From?

Source:msn. health & fitness

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