Categories
Ailmemts & Remedies

Abdominal Aortic Aneurysm(AAA)

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Definition:
The aorta is the largest artery in your body, and it carries oxygen-rich blood pumped out of, or away from, your heart. Your aorta runs through your chest, where it is called the thoracic aorta. When it reaches your abdomen, it is called the abdominal aorta. The abdominal aorta supplies blood to the lower part of the body. In the abdomen, just below the navel, the aorta splits into two branches, called the iliac arteries, which carry blood into each leg.

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When a weak area of the abdominal aorta expands or bulges, it is called an abdominal aortic aneurysm (AAA). The pressure from blood flowing through your abdominal aorta can cause a weakened part of the aorta to bulge, much like a balloon. A normal aorta is about 1 inch (or about 2 centimeters) in diameter. However, an AAA can stretch the aorta beyond its safety margin as it expands. Aneurysms are a health risk because they can burst or rupture. A ruptured aneurysm can cause severe internal bleeding, which can lead to shock or even death.

Less commonly, AAA can cause another serious health problem called embolization. Clots or debris can form inside the aneurysm and travel to blood vessels leading to other organs in your body. If one of these blood vessels becomes blocked, it can cause severe pain or even more serious problems, such as limb loss.

Each year, physicians diagnose approximately 200,000 people in the United States with AAA. Of those 200,000, nearly 15,000 may have AAA threatening enough to cause death from its rupture if not treated.

Fortunately, especially when diagnosed early before it causes symptoms, an AAA can be treated, or even cured, with highly effective and safe treatments.

Symptoms:
Although you may initially not feel any symptoms with AAA, if you develop symptoms, you may experience one or more of the following:

*A pulsing feeling in your abdomen, similar to a heartbeat

*Severe, sudden pain in your abdomen or lower back. If this is the case, your aneurysm may be about to burst.

*On rare occasions, your feet may develop pain, discoloration, or sores on the toes or feet because of material shed from the aneurysm

*If your aneurysm bursts, you may suddenly feel intense weakness, dizziness, or pain, and you may eventually lose consciousness. This is a life-threatening situation and you should seek medical attention immediately.

Causes:
Physicians and researchers are not quite sure what actually causes an AAA to form in some people. The leading thought is that the aneurysm may be caused by inflammation in the aorta, which may cause its wall to weaken or break down. Some researchers believe that this inflammation can be associated with atherosclerosis (also called hardening of the arteries) or risk factors that contribute to atherosclerosis, such as high blood pressure (hypertension) and smoking. In atherosclerosis fatty deposits, called plaque, build up in an artery. Over time, this buildup causes the artery to narrow, stiffen and possibly weaken. Besides atherosclerosis, other factors that can increase your risk of AAA include:

*Being a man older than 60 years

*Having an immediate relative, such as a mother or brother, who has had AAA

*Having high blood pressure

*Smoking

Your risk of developing AAA increases as you age. AAA is more common in men than in women.

Tests and Diagnosis:
Most abdominal aortic aneurysms are found during an examination for another reason. For example, during a routine exam, your doctor may feel a pulsating bulge in your abdomen, though it’s unlikely your doctor will be able to hear signs of an aneurysm through a stethoscope. Aortic aneurysms are often found during routine medical tests, such as a chest X-ray or ultrasound of the heart or abdomen, sometimes ordered for a different reason.

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Abdominal aortic aneurysms that are not causing symptoms are most often found when a physician is performing an imaging test, such as an ultrasound or CT scan, for another condition. Sometimes your physician may feel a large pulsing mass in your abdomen on a routine physical examination.  If your physician suspects that you may have AAA, he or she may recommend one of the following tests to confirm the suspicion:

*Abdominal ultrasound

*Computed tomography (CT) scan

*Magnetic resonance imaging (MRI)

Modern Treatment:
Watchful waiting
If your AAA is small, your physician may recommend “watchful waiting,” which means that you will be monitored every 6-12 months for signs of changes in the aneurysm size. Your physician may schedule you for regular CT scans or ultrasounds to watch the aneurysm. This method is usually used for aneurysms that are smaller than about 2 inches (roughly 5.0 to 5.5 centimeters) in diameter. If you also have high blood pressure, your physician may prescribe blood pressure medication to lower the pressure on the weakened area of the aneurysm. If you smoke, you should obtain help to stop smoking. An aneurysm will not “go away” by itself. It is extremely important to continue to follow up with your physician as directed because the aneurysm may enlarge to a dangerous size over time. It could eventually burst if this is not detected and treated.
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Open Surgical aneurysm repair…….click & see
A vascular surgeon may recommend that you have a surgical procedure called open aneurysm repair if your aneurysm is causing symptoms, or is larger than about 2 inches (roughly 5.0 to 5.5 centimeters), or is enlarging under observation. During an open aneurysm repair, also known as surgical aneurysm repair, your surgeon makes an incision in your abdomen and replaces the weakened part of your aorta with a tube-like replacement called an aortic graft. This graft is made of a strong, durable, man-made plastic material, such as Dacron®, in the size and shape of the healthy aorta. The strong tube takes the place of the weakened section in your aorta and allows your blood to pass easily through it. Following the surgery, you may stay in the hospital for 4 to 7 days. Depending upon your circumstances, you may also require 6 weeks to 3 months for a complete recovery. More than 90 percent of open aneurysm repairs are successful for the long term.

Endovascular stent graft…….....click & see
Instead of open aneurysm repair, your vascular surgeon may consider a newer procedure called an endovascular stent graft. Endovascular means that the treatment is performed inside your artery using long, thin tubes called catheters that are threaded through your blood vessels. This procedure is less invasive, meaning that your surgeon will usually need to make only small incisions in your groin area through which to thread the catheters. During the procedure, your surgeon will use live x-ray pictures viewed on a video screen to guide a fabric and metal tube, called an endovascular stent graft  (or endograft), to the site of the aneurysm. Like the graft in open surgery, the endovascular stent graft also strengthens the aorta. Your recovery time for endovascular stent grafting is usually shorter than for the open surgery, and your hospital stay may be reduced to 2 to 3 days. However, this procedure requires more frequent follow-up visits with imaging procedures, usually CT scans, after endograft placement to be sure the graft continues to function properly.  Also, the endograft is more likely to require periodic maintenance procedures than does the open procedure. In addition, your aneurysm may not have the shape that is suitable for this procedure, since not all patients are candidates for endovascular repair because of the extent of the aneurysm, or its relationship to the renal (kidney) arteries, or other issues. While the endovascular stent graft may be a good option for some patients who have suitable aneurysms and who have medical conditions increasing their risk, in some other cases, open aneurysm repair may still be the best way to cure AAA. Your vascular surgeon will help you decide what is the best method of treatment for your particular situation.

Endovascular treatment of AAA……...click & see
In the recent years, the endoluminal treatment of Abdominal Aortic Aneurysms has emerged as a minimally invasive alternative to open surgery repair. The first endoluminal exclusion of an aneurysm took place in Argentina by Dr. Parodi and his colleagues in 1991. The endovascular treatment of aortic aneurysms involves the placement of an endo-vascular stent via a percutaneous technique (usually through the femoral arteries) into the diseased portion of the aorta. This technique has been reported to have a lower mortality rate compared to open surgical repair, and is now being widely used in individuals with co-morbid conditions that make them high risk patients for open surgery. Some centers also report very promising results for the specific method in patients that do not constitute a high surgical risk group.

There have also been many reports concerning the endovascular treatment of ruptured Abdominal Aortic Aneurysms, which are usually treated with an open surgery repair due to the patient’s impaired overall condition. Mid-term results have been quite promising.[citation needed] However, according to the latest studies, the EVAR procedure doesn’t carry any overall survival benefit.

Endovascular treatment of other aortic aneurysms
The endoluminal exclusion of aortic aneurysms has seen a real revolution in the very recent years. It is now possible to treat thoracic aortic aneurysms, abdominal aortic aneurysms and other aneurysms in most of the body’s major arteries (such as the iliac and the femoral arteries) using endovascular stents and avoiding big incisions. Still, in most cases the technique is applied in patients at high risk for surgery as more trials are required in order to fully accept this method as the gold standard for the treatment of aneurysms.

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Prevention
Attention to patient’s general blood pressure, smoking and cholesterol risks helps reduce the risk on an individual basis. There have been proposals to introduce ultrasound scans as a screening tool for those most at risk: men over the age of 65. The tetracycline antibiotic, Doxycycline is currently being investigated for use as a potential drug in the prevention of aortic aneurysm due to its metalloproteinase inhibitor and collagen stabilising properties.

Research
Stanford University is conducting research to gather information on AAA risk factors, and to evaluate the effectiveness of an exercise program at preventing the growth of small AAAs in older individuals.

Disclaimer: This information is not meant to be a substitute for professional medical advise or help. It is always best to consult with a Physician about serious health concerns. This information is in no way intended to diagnose or prescribe remedies.This is purely for educational purpose.

 

Resources:
http://www.vascularweb.org/patients/NorthPoint/Abdominal_Aortic_Aneurysm.html
http://en.wikipedia.org/wiki/Aortic_aneurysm
http://www.mayoclinic.com/health/aortic-aneurysm/ds00017/dsection=tests-and-diagnosis

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Categories
Diagnonistic Test

Electrophysiological Testing of the Heart

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Definition:
An electrophysiology (EP) study is a test that records the electrical activity and the electrical pathways of your heart. This test is used to help determine the cause of your heart rhythm disturbance and the best treatment for you. During the EP study, your doctor will safely reproduce your abnormal heart rhythm and then may give you different medications to see which one controls it best or to determine the best procedure or device to treat your heart rhythm.
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Sometimes doctors will recommend a treatment called ablation that can be done during EPS testing. Ablation uses electricity to kill the cells in the heart muscle that seem to cause the abnormal rhythm.

You may click to see:->Electrophysiology Study

 

Why Do you Need an Electrophysiology Study?
*To determine the cause of an abnormal heart rhythm.

*To locate the site of origin of an abnormal heart rhythm.

*To decide the best treatment for an abnormal heart rhythm.

Sometimes an EP study is conducted before implantable cardioverter/defibrillator (ICD) placement to determine which device is best and afterwards to monitor treatment success.

How do you prepare for the test?
*You will need to sign a consent form giving your doctor permission to perform this test. Tell your doctor if you have ever had an allergic reaction to lidocaine or the numbing medicine used at the dentist’s office. Also tell your doctor if you have ever had an allergic reaction to any heart medicines.

*Talk with your doctor ahead of time if you are taking insulin, or if you take aspirin, nonsteroidal antiinflammatory drugs, or other medicines that affect blood clotting. It may be necessary to stop or adjust the dose of these medicines before your test. Most people need to have a blood test done some time before the procedure to make sure they are not at high risk for bleeding complications.

*Your doctor may tell you not to eat anything for 12 or more hours before the test. A few people require an anti-anxiety medicine which occasionally causes nausea, and therefore some doctors prefer to have you come with an empty stomach. You might need to plan to spend the night in the hospital afterwards for recovery.

*Ask your doctor what medications you are allowed to take. Your doctor may ask you to stop certain medications one to five days before your EP study. If you have diabetes, ask your doctor how you should adjust your diabetes medications.

*Do not eat or drink anything after midnight the evening before the EP study. If you must take medications, take them only with a small sip of water.

*When you come to the hospital, wear comfortable clothes. You will change into a hospital gown for the procedure. Leave all jewelry or valuables at home.

*Your doctor will tell you if you can go home or must stay in the hospital after the procedure. If you are able to go home, bring a companion to drive you home.

What happens when the test is performed?
The test is done by a specialist using equipment and cameras in the cardiology department. You wear a hospital gown and lie on your back during the procedure. You have an IV (intravenous) line placed in a vein in case you need medicines or fluid during the procedure. Your heart is monitored during the test.

A catheter (a hollow, sterile tube that resembles spaghetti) is inserted through the skin into a blood vessel-typically in your groin, but possibly in the neck or arm. Before the catheter is placed, medicine through a small needle is used to numb the skin and the tissue underneath the skin in that area. The numbing medicine usually stings for a second. A needle on a syringe is then inserted, and some blood is drawn into the syringe, so that the doctor knows exactly where the blood vessel is located. One end of a wire is threaded into the blood vessel through the needle and the needle is pulled out, leaving the wire temporarily in place. This wire is several feet long, but only a small part of it is inside your blood vessel. The catheter can then be slipped over the outside end of the wire and moved forward along it like a long bead on a string, until it is in place with one end inside the blood vessel. The wire is pulled out of the catheter, leaving the catheter in place. Now the catheter can be moved easily forwards and backwards inside your blood vessel by the doctor, who holds the outside end of the catheter while using special controls to point the tip of the catheter in different directions. The doctor carefully moves the catheter to the large blood vessels in your chest and into the chambers of your heart.

As your physician maneuvers the catheter, he or she watches a live video x-ray to know exactly where the catheter is. Instruments on the tip of the catheter allow it to sense electrical patterns from your heart and also to deliver small electrical shocks to the heart muscle (or a stronger electrical burn if you are having ablation). The electrical shocks, too small for you to feel, are used to “tickle” the heart muscle in different places to see if your abnormal rhythm is triggered by one sensitive area of your heart. If the rhythm changes, your doctor gives you small doses of different medicines through this catheter to see which ones work best to change the rhythm back to normal. In some cases the doctor may need to give your heart some additional mild shocks to get it back into a normal rhythm. Because this catheter is in place inside your heart and can give the shocks directly to the heart muscle, very small amounts of electricity are used.

After the catheter has been pulled out, a pressure bandage (basically a thick lump of gauze) is taped tightly to your groin to reduce bleeding. The test usually requires one to two hours to perform.

Many patients are able to feel palpitations (an irregular or fast heartbeat) from the rhythm changes. A few patients also experience shortness of breath or dizziness when they are not in a normal heart rhythm. Other than the brief sting of the numbing medicine and some soreness in your groin area afterward, you are not likely to feel any pain. For some people, the procedure provokes anxiety. Some patients also have a difficult time lying still for the time it takes to perform this test.
What Can you Expect During the Electrophysiology Study?
*You will lie on a bed and the nurse will start an intravenous (IV) line into your arm or hand. This is so you can receive medications and fluids during the electrophysiology study. You will be given a medication through your IV to relax you and make you drowsy, but it will not put you to sleep.

*The nurse will connect you to several monitors.
Your groin will be shaved and cleansed with an antiseptic solution. Sterile drapes are used to cover you, from your neck to your feet. A soft strap will be placed across your waist and arms to prevent your hands from coming in contact with the sterile field.

An electrophysiologist (a doctor who specializes in the diagnosis and treatment of abnormal heart rhythms) will numb your groin with medication and then insert several catheters into the vein in your groin. Guided by the fluoroscopy machine, the catheters are threaded to your heart. The catheters sense the electrical activity in your heart and are used to evaluate your heart’s conduction system. The doctor will use a pacemaker to deliver the electrical impulses through one of the catheters to increase your heart rate.

You may feel your heart beating faster or stronger. Your nurses and doctor will want to know about any symptoms you are feeling. If your arrhythmia occurs, your doctor may give you medications through your IV to test their effectiveness in controlling it. If necessary, a small amount of energy may be delivered by the patches on your chest to bring back a normal heart rhythm. Based on the information collected during the study, the doctor may continue with an ablation procedure or device implant (pacemaker or ICD).

The EP study takes about two to four hours to perform. However, it can take longer if additional treatments such as catheter ablation are performed at the same time.

Risk Factors:
There are significant risks from this procedure. Most important, some abnormal heart rhythms (arrhythmia) can be life-threatening, and your doctors will purposefully cause you to go through a few extra episodes of arrhythmia during the testing. If your doctors recommend electrophysiologic testing, they feel that this is a risk worth taking because it will allow them to take better care of you in the future. Because you are right in the lab and attached to a monitor while you undergo the rhythm changes, it is easy for them to treat you should your arrhythmia occur and cause you symptoms.

Ablation has some additional risks, because it intentionally causes some scarring of a small part of the heart muscle. Complications are rare, but new rhythm changes can occur. A very rare complication occurs if the ablation instrument burns a hole through the heart muscle. This causes bleeding and may require immediate surgery.

There are some more minor risks from the test. Among them is bleeding from the place where the catheter was inserted. If bleeding occurs but the blood collects under the skin, it can form a large painful bruise called a hematoma. A few people are allergic to the medicines used in the procedure, and this can cause a rash or other symptoms.

Must you do anything special after the test is over?
You will need to lie flat for around six hours after this procedure. If you received anti-anxiety medicine through your IV during the procedure, you might feel sleepy at the end of the procedure and you might not remember much of the test. You should not drive or drink alcohol for the rest of the day.

Depending on what happened during your test, you might need to wear a heart monitor in the hospital for a few hours or overnight.

What Happens After the EP Study?
The doctor will remove the catheters from your groin and apply pressure to the site, to prevent bleeding. You will be on bed rest for about one to two hours.

An EP study can be frightening, but this test allows the doctor to decide the best treatment for you. In many cases, EP testing and the therapy following can greatly reduce the likelihood of spontaneous arrhythmia. If you have any questions, do not hesitate to ask your doctor or nurse.

How long is it before the result of the test is known?
Your doctors can tell you how the testing went as soon as it is over. If you had ablation done, the results will not be certain until you have had some time to see if your arrhythmia seems to be under control after the treatment.

Resources:
https://www.health.harvard.edu/fhg/diagnostics/electrophysiological-testing-of-the-heart.shtml
http://www.webmd.com/heart-disease/guide/diagnosing-electrophysiology

http://www.londoncardiac.ca/pages/bfs.html

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Categories
Featured Herbs & Plants

Garlic Tales

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Scientists are continuously trying to unvail  the secrets of the garlic, to zero in on what makes the herb so beneficial.

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A herb that is a part of almost every Indian kitchen continues to make news. Garlic, or Allium sativum, one of the oldest medicinal herbs known to human beings, is now in laboratories, while scientists look at what makes it so beneficial.

Indeed, garlic seems to possess near-magical health properties. Yet science has not found it an easy herb to understand. Despite tall claims from practitioners of alternative medicine, no one clearly knows how good garlic is and why it is considered to be so beneficial. But now scientists are rapidly unravelling its secrets.

Over the years, people with varying backgrounds have claimed that the bulb is good for controlling blood pressure and reducing cholesterol. It is supposed to have anti-inflammatory, antimicrobial, antiviral, antioxidant and anticoagulant properties, apart from a few other benefits. There is now good evidence that most of these claims are true. And scientists have recently discovered new properties as well: it can reduce blood sugar levels, and is thus good for controlling diabetes. Yet conventional wisdom is not always right: it may not, after all, reduce cholesterol.

While evidence on the utility mounts, scientists are also beginning to understand why. For example, garlic’s antioxidant properties have been a mystery to scientists. It has been known to be a powerful antioxidant (a compound that destroys damaging free radicals); in fact a bit too powerful for comfort. It has a compound called allicin that is an antioxidant, but its structure could not explain its power. Till now, that is.

Derek Pratt, professor of chemistry at Queen’s University in Canada, has found out why garlic is so powerful.

A compound akin to allicin is found in other plants of the family alliaceae — such as shallots, onions and leeks. However, none of these plants has garlic’s beneficial powers. This is because the allicin found in garlic breaks down into another compound called sulphenic acid, which rapidly cleans up free radicals in its path. Without this breakdown, allicin cannot be so effective an antioxidant.

“This compound is the most powerful antioxidant known to us,” says Pratt, who published his results last week in the journal Angewandte Chemie.

While its efficacy in dealing with free radicals is now beyond doubt, garlic is probably not so effective in reducing bad cholesterol, the Low Density Lipoproteins (LDL). Several studies on its effect on blood cholesterol led to conflicting results, but one in Stanford University more than a year ago was probably the most conclusive. This six-month-long study found no correlation between consumption of garlic and reduction of LDL. “We are convinced now that garlic does not reduce bad cholesterol,” Christopher Gardner, the Stanford professor who led the research, had told Knowhow soon after publishing the results of the study.

But that does not mean it is not useful in treating high cholesterol. Its antioxidant properties are useful in treating cardiovascular diseases in general, and even for treating high cholesterol. This is because garlic suppresses the oxidation of LDL in the blood. LDL is called bad cholesterol because it sticks to the artery walls and clogs the arteries. However, it is not LDL that actually does the damage but oxidised LDL. Several studies have shown that garlic suppresses oxidation of LDL and thus prevents the formation of plaques in the arteries. It makes bad cholesterol not so bad.

“Garlic does reduce LDL oxidation,” stresses Khalid Rahman, reader in the physiological biochemistry at Liverpool University in the UK, who has conducted several lab and clinical studies on the herb.

There is increasing evidence that it can lower blood pressure, particularly when BP is elevated only mildly. A recent meta-analysis (analysis of all published literature) by scientists at the University of Adelaide showed that it does lower blood pressure. However, the scientists also warn that the evidence is not strong enough to use garlic as the only means of therapy.

These results are from clinical studies, which mean that they have been done on people. The results are equally encouraging in pre-clinical studies done in the laboratory. There, the herb has been shown to be anti-inflammatory and anticoagulant. It may be able to help dissolve clots and improve blood circulation. A few months ago, Japanese scientists (at the RIKEN and other institutions) showed that it could lower blood glucose levels in rats.

The list of beneficial properties is actually lengthening every day, but the topic is not without its controversy either.

This is because there are some studies showing that garlic had no effect on lowering blood pressure or reducing cholesterol, while some others showed that it did do so. This variability, fortunately, is not hard to explain. Scientists explain this contradiction through differences in the duration of the trials, and also on the variability in the properties of garlic. “The factors influencing a clinical study with garlic are difficult to control,” says Pratt.

Although we know that it is beneficial, not all kinds of garlic may act in the same manner. “In my view there is a group of people who are non-responders to garlic, like to any other medication,” says Rahman.

However, garlic has caught the attention of hundreds of scientists throughout the world. We will learn more about this wonder herb in the coming years.

Sources: The Telegraph (Kolkata, India)

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Categories
Health Quaries

Some Health Quaries & Answers

Q: All the people in my apartment block are afflicted by sneezing and skin allergies. Recently I discovered that a neighbour rears parrots. Could it be due to this?

…………………………..

A: Parrots and other birds can cause allergies. Mites that live on the birds’ dander or feathers cause the allergies. The problem will persist as long as the parrots are there. But if they are confined to his apartment, it is unlikely that the allergens will affect all of you. So, before you blame the parrot fancier, please check if there are other allergens in the environment. Many people are allergic to incense sticks, mosquito repellents, burning camphor, or pollen.

Untreated schizophrenia:

Q: My brother has schizophrenia. My parents do not want to have him treated as they are afraid of what our relatives will say if the news leaks out. They are also afraid it will hamper my marriage prospects.

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A: Mental illnesses are due to biochemical imbalances in the brain. They are chronic illnesses, like diabetes, high blood pressure and arthritis. They require medication, rehabilitation and regular follow up visits to a psychiatrist. Medication is also needed for rectification. Unfortunately 75 per cent of the people do not accept this. The mentally ill are often denied treatment by their families. You need to take a firm stand in this regard and insist on treatment for your brother.

Boils on my face

Q: I get painful boils (not pimples) on my face, and my arms and legs also. After a few days they turn yellow and burst, discharging blood stained yellow pus.

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A: Some people carry an organism called Staphylococcus on their skin and in their nose. The bacteria live in harmony with the person. When the skin is injured, they get access to the deeper layers of the skin. They then form these boils.

Bacteria have cell walls that can be broken by certain chemicals like trichlorocarbanilide (TCC). Some soaps like Neko and Dial contain this compound. The total fat content of these soaps is adjusted to be lethal for these bacteria. Bathe twice a day using one of these. On the appearance of a boil, apply a bactericidal ointment like mupirocin or bacitracin after a bath. Apply the same ointment to the nostrils twice a day using buds. Eventually the frequency and intensity of the attacks will reduce.

Low back pain

Q: My mother has terrible backache and the doctor says it is spondolisthesis. Is surgery essential?

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A: Spondolisthesis is a term used to describe the slipping forward of the lumbar (back) vertebrae on the sacrum (tailbone). The degree of the slip is measured through CT scans. Surgery is required if it is grade 2 or higher. She can try conservative methods like physiotherapy and a lumbo-sacral support belt initially. As long as she can manage, it may be better to do so as surgery has its own inherent risks. After surgery physical rehabilitation and exercises are essential.

Missing fingers

Q: My daughter was born with the tips of two fingers of her left hand missing. The paediatrician said it is amniotic band syndrome. Will my next child also be affected?

A: The amniotic sac lines the inside of the uterus during pregnancy. The baby floats in this sac in a fluid called amniotic fluid. At times the sac ruptures in a place or two. This results in the formation of fibrous bands in the fluid. As the uterus grows the bands tighten. If it occurs around a finger, that may get severed (congenital amputation). The fingers can be reconstructed through plastic surgery. The condition is non-recurrent and your next child is unlikely to inherit it.

Reconstruction of the fingers with plastic surgery is the remedy.

Martial dad

Q: My father, 70 years, wants to join a Tai-chi class. Is that advisable? I have heard that it is a form of martial art from China which consists of hundreds of combinations of graceful and flowing movements.

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A: Taught well by an expert and practised scientifically, Tai Chi improves balance, posture and strength. It provides flexibility and aligns painful arthritic and ageing joints. It also helps focus and improves concentration. Hence it has a positive effect on loss of memory, forgetfulness and mild dementia related to old age. The rhythmic breathing tones circulation, relaxes the mind, eases tension and aids restful sleep at night.

The advantages are many. In short, it is an ideal form of exercise for older people. You should be glad that your father wants to join a class.

Sources: The Telegraph (Kolkata, India)

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Categories
News on Health & Science

New Anti-Cancer Compound Found

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A marine compound discovered off the coast of Key Largo in Florida inhibits cancer cell growth in lab tests and is likely to prompt the development of effective new drugs.

The University of Florida (UF)-patented compound, largazole, is derived from cyanobacteria that grow on coral reefs. It is being described as one of the most promising finds since the college’s marine lab was established three years ago.

The molecule’s natural chemical structure and its ability to inhibit cancer cell growth were first described in the Journal of American Chemical Society in February, and the lab synthesis and description of the molecular basis for its anti-cancer activity appeared on July 2.

“It’s exciting because we’ve found a compound in nature that may one day surpass a currently marketed drug or could become the structural template for rationally designed drugs with improved selectivity,” said Hendrik Luesch, assistant professor in UF’s Department of Medicinal Chemistry and the study’s principal investigator.

Largazole, discovered and named by Luesch for its Florida location and structural features, seeks out a family of enzymes called histone deacetylase, or HDAC. Overactivity of certain HDACs has been associated with several cancers such as prostate and colon tumours, and inhibition of HDACs can activate tumour-suppressor genes that have been silenced in these cancers.

Although scientists have been probing the depths of the ocean for marine products since the early 1960s, many pharmaceutical companies lost interest before researchers could deliver useful compounds because natural products were considered too costly and time-consuming to research and develop.

Many common medications, from pain relievers to cholesterol-reducing statins, stem from natural products that grow on the earth, but there is literally an ocean of compounds yet to be discovered in our seas.

Only 14 natural marine products developed are in clinical trials today, Luesch said, and one drug recently approved in Europe is the first-ever marine-derived anti-cancer agent.

“Marine study is in its infancy”, said William Fenical, professor of oceanography and pharmaceutical sciences at the University of California, San Diego. “The ocean is a genetically distinct environment and the single, most diverse source of new molecules to be discovered”.

HDACs are already targeted by a drug approved for cutaneous T-cell lymphoma manufactured by the global pharmaceutical company Merck & Co. Inc. However, UF’s compound does not inhibit all HDACs equally, meaning a largazole-based drug might result in improved therapies and fewer side effects, Luesch said.

Luesch said that, within the next few months, he plans to study whether largazole reduces or prevents tumour growth in mice. Luesch has several other anti-tumour natural products from Atlantic and Pacific cyanobacteria in the pipeline.

These results were presented on Thursday at an international natural products scientific meeting in Athens.

Sources: The Times Of Imdia

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