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Herbs & Plants

Gillenia stipulata

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Botanical Name : Gillenia stipulata
Family: Rosaceae
Genus: Gillenia
Species: G. stipulata
Kingdom: Plantae
Order: Rosales

Synonym(s): Porteranthus stipulatus; spiraea stipulata, Porteranthus stipulatus. (Muhl. ex Willd.)Britt.

Common Name : American Ipecacuanna, American ipecac

Habitat : Gillenia stipulata   is native to  Eastern N. America – New York to Indiana and Kansas, south to Georgia, Louisiana and Oklahoma. It grows in woods, thickets and rocky slopes.

Description:
Gillenia stipulata is a  herbaceous, perennial  plant   growing to 1.2 m (4ft).  It is hardy to zone (UK) 5. It is in flower from May to June.  The stem  is erect, glabrous to pubescent, branching, multiple from base, sub-hollow, greenish to red above, from caudex, rhizomatous.. The flowers are hermaphrodite (have both male and female organs) and are pollinated by Insects.

Leaves – Alternate, stipulate, short-petiolate, trifoliolate. Stipules large, foliaceous, serrate, ovate, +/-2.5cm long and broad, pubescent below, glabrous ir sparse pubescent above. Leaflets sessile, linear-lanceolate, to 9cm long, 2cm broad, serrate, pubescent below, sparse pubescent above, central leaflet slightly larger than lateral leaflets. Leaflets of lowest leaves pinnatifid.

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Inflorescence – Axillary and terminal loose few-flowered panicles. Each divisions of inflorescence subtended by reduced foliaceous bract.

Flowers – Petals 5, white, acute to acuminate, 1.2cm long, 3-4mm broad, glabrous, oblong, clawed. Claw to 3mm long. Stamens 20, borne at edge of hypanthium, in two sets. Filaments white, glabrous, 2mm long. Anthers tan, 1mm in diameter. Pistils 5, distinct. Styles white, 3mm long, glabrous. Ovaries yellow-green, 1.9mm long. Hypanthium tube 5-6mm long, 3-4mm in diameter, greenish-white to reddish, truncate at base, glabrous. Sepals 5, acute, 1.1mm long, with some pubescence internally near apex. Follicles to 8mm long, glabrous, with +/-3 seeds.

A common name for this plant is “American Ipecac” because the plant had been used by natives as a laxative and emetic. This is not, however, the common Ipecac of modern medicine. Today’s Ipecac comes from Cephaelis ipecacuanha, a member of the Rubiaceae from South America.

Cultivation:
Easily grown in a rather moist but well-drained lime-free peaty soil in semi-shade. Succeeds in a sunny position but requires shade at the hottest part of the day.

Propagation:
Seed – sow spring or autumn in a cold frame. Prick out the seedlings when they are large enough to handle and grow on for the first year in a lightly shaded area of the greenhouse or cold frame. Plant out in late spring and protect from slugs until well established. Division in spring or autumn.
Medicinal Uses:
The dried powered root bark is cathatric, slightly diaphoretic,a mild and efficient  emetic,expectorant and tonic. Minute dosesare used internally in the treatment of colds, chronic diarrhea, constipation, asthma and other bronchial complications. The root have been used externally in the treatment of rhematism. A cold infution of the roots has been given , or the root   chewed  in the treatment of bee and insects stings.The roots are harvested in the autumn, the bark is removed and dried for later use. A tea made from the whole plant is strong laxative and emitic.Minute doses are used internally in the treatment of colds, indigestion, asthma and hepatitis.A poultice or wash is used in the treatment of rhematism,bee stings and swellings.A decoction or strong infution of the whole plant has been taken a pint at a time as an emitic.A poultice of the plant  has been used to treat leg swellings. The plant has been used in the treatment of toothaches.

Disclaimer:
The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider.

Resources:

http://aggie-horticulture.tamu.edu/ornamentals/cornell_herbaceous/plant_pages/Gilleniastipulata.html

http://www.robsplants.com/plants/GilleStipu

http://www.missouriplants.com/Whitealt/Gillenia_stipulata_page.html

http://en.wikipedia.org/wiki/Gillenia_stipulata

http://www.herbnet.com/Herb%20Uses_IJK.htm

http://www.thealpinegarden.com/woodlandusa.htm

http://www.pfaf.org/user/Plant.aspx?LatinName=Gillenia+stipulata

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Herbs & Plants

Aristolochia debilis

Botanical Name :Aristolochia debilis
Family: Aristolochiaceae
Subfamily: Aristolochioideae
Genus: Aristolochia
Species: Aristolochia debilis
Regnum: Plantae
Cladus: Angiosperms
Cladus: Magnoliids
Order: Piperales

Synonyms : A. recurvilabra. Hance.

Common Name : Ma Dou Ling,  Birthwort, Frail

Habitat :Aristolochia debilis is native to  E. Asia – C,hina, Japan. It grows in the roadside thickets and meadows in lowland, C. and S. Japan and in China.

Description:
Aristolochia debilis is a perennial herb growing to 1 m (3ft 3in) by 1 m (3ft 3in).
It is hardy to zone 8. It is in flower from Jul to August, and the seeds ripen from Sep to October. The flowers are hermaphrodite (have both male and female organs) and are pollinated by Flies.

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The plant prefers light (sandy), medium (loamy) and heavy (clay) soils and requires well-drained soil.The plant prefers acid, neutral and basic (alkaline) soils..It can grow in semi-shade (light woodland) or no shade.It requires moist soil.

Cultivation:
Prefers a well-drained loamy soil, rich in organic matter, in sun or semi-shade. Succeeds in ordinary garden soil. This species is not very hardy in Britain, tolerating temperatures down to about -5°c. Most species in this genus have malodorous flowers that are pollinated by flies.

Propagation:
Seed – best sown in a greenhouse as soon as it is ripe in the autumn. Pre-soak stored seed for 48 hours in hand-hot water and surface sow in a greenhouse. Germination usually takes place within 1 – 3 months at 20°c. Stored seed germinates better if it is given 3 months cold stratification at 5°c. When large enough to handle, prick the seedlings out into individual pots and grow them on in the greenhouse for their first winter. Plant out in late spring or early summer after the last expected frosts. Division in autumn. Root cuttings in winter[

Edible Uses:Leaves are edible.They are cooked. It is said that the leaves of this species are not poisonous but caution is advised.

Medicinal Uses:
Alterative;  Anodyne;  Antibacterial;  Antifungal;  Antiinflammatory;  Antitussive;  Carminative;  Cytotoxic;  Diuretic;  Expectorant;  Hypotensive;
Stomachic;  Tonic.

Alterative, antibacterial, antifungal, diuretic. Stimulates energy circulation. The fruit and its capsule are antiasthmatic, antiseptic, antitussive and expectorant. It is used internally in the treatment of asthma and various other chest complaints, haemorrhoids and hypertension. The root is anodyne and anti-inflammatory. It is used internally in the treatment of snakebite, gastric disorders involving bloating, and is clinically effective against hypertension. It is harvested in the autumn and dried for later use. The whole plant is antitussive, carminative, stimulant and tonic. The root contains aristolochic acid. This has anti-cancer properties and can be used in conjunction with chemotherapy and radiotherapy. Aristolochic acid can also be used in the treatment of acute and serious infections such as TB, hepatitis, liver cirrhosis and infantile pneumonia. It also increases the cellular immunity and phagocytosis function of the phagocytic cells. Aristolochic acid is said to be too toxic for clinical use

Internally used for arthritis, purulent wounds, hypertension, snake and insect bites, and gastric disorders involving bloating (roots); for asthma, wet coughs, bronchitis, hypertension and hemorrhoids (fruits). Indications: heat in the lungs manifested as cough with profuse yellow sputum and asthma.  The fruit (Madouling) is used with Loquat Leaf, Peucedanum root, Mulberry bark and Scutellaria root.  Deficiency of the lungs manifested as cough with scanty sputum or with bloody sputum and shortness of breath.  Fruit is used with Glehnia root, Ophiopogon root, Aster root and Donkey hide gelatin.

Known Hazards: No specific details for this species is known  but most members of this genus have poisonous roots and stems. The plant contains aristolochic acid, this has received rather mixed reports on its toxicity. According to one report aristolochic acid stimulates white blood cell activity and speeds the healing of wounds, but is also carcinogenic and damaging to the kidneys. Another report says that it is an active antitumour agent but is too toxic for clinical use. Another report says that aristolochic acid has anti-cancer properties and can be used in conjunction with chemotherapy and radiotherapy and that it also increases the cellular immunity and phagocytosis function of the phagocytic cells

Disclaimer:
The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider.

Resources:
http://www.pfaf.org/user/Plant.aspx?LatinName=Aristolochia%20debilis
http://www.herbnet.com/Herb%20Uses_AB.htm
http://species.wikimedia.org/wiki/Aristolochia_debilis
http://www.exot-nutz-zier.de/images/prod_images/Aristolochia_debilis.jpg
http://www.georgiavines.com/cart/index.php?main_page=product_info&cPath=9_10&products_id=118

http://www.asianflora.com/Aristolochiaceae/Aristolochia-debilis.htm

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Herbs & Plants

Sarsaparilla (Smilax sarsaparilla )

Botanical Name : Smilax sarsaparilla
Family : Smilacaceae
Genus: Smilax
Kingdom: Plantae
Order: Liliales
Species: S. regelii
Common Names :  Sarsaparilla , zarzaparrilla,  Honduran Sarsaparilla,  Jamaican Sarsaparilla., khao yen, saparna, smilace, smilax, zarzaparilla, jupicanga

Habitat :Smilax sarsaparilla is native to Central America.

Description:
It is a perennial trailing vine with prickly stems that . Common names include It is known in Spanish as zarzaparrilla, which is derived from the words zarza, meaning “shrub,” and parrilla, meaning “little grape vine.”

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Subshrubs or vines ; rhizomes black, knotted, 5-6 × 2 cm, often with white to pinkish stolons. Stems perennial , prostrate to clambering , branching, slender, to 1 m , ± woody, densely woolly-pubescent, usually prickly (especially at base ). Leaves mostly evergreen , ± evenly disposed; petiole 0.05-0.25 cm, often longer on sterile shoots ; blade gray-green, drying to ashy gray-green, obovate to ovate-lanceolate, with 3 prominent veins, 6-10.5 × 5-8 cm, glabrous adaxially, densely puberulent abaxially, base cordate to deeply notched , margins entire, apex bluntly pointed . Umbels 1-7, axillary to leaves, 5-16-flowered, loose , spherical ; peduncle 0.2-0.8 cm, shorter than to 1.5 as long as petiole of subtending leaf. Flowers: perianth yellowish; tepals 3-4 mm; anthers much shorter than filaments ; ovule 1 per locule; pedicel thin, 0.1-0.4 cm. Berries red, ovoid , 5-8 mm, with acute beaks , not glaucous. (source   :Flora of North America)

The red, pointed fruits and densely pubescent herbage of Smilax pumila are distinctive.

The name Smilax humilis Miller, which predates S. pumila by 20 years and recently has been determined to apply also to this species, has been proposed for rejection (J. L. Reveal 2000). If that proposal is not adopted, the correct name will be S. humilis.

Medicinal Uses:
Common Uses: Eczema * Psoriasis * Rheumatoid Arthritis *
Properties:  Depurative* Antibacterial* AntiViral* Tonic* Anti-inflammatory* Appetite Depressant/Obesity* Antiscrofulous*
Parts Used: Root
Constituents: parillin (smilacin), glucoside, sarsapic acid, saponins: sarsasaponin, sarsaparilloside, many flavonioids and starch

For many years, people thought sarsaparilla had testosterone in it, but there is none present, or for that matter in any plant studied so far. The spicy, pleasant smelling root is what gave old fashioned root beer its bite and is the part used medicinally. The exact mechanism of action has not been identified, however it is thought that the phytosterols it contains stimulate hormone-like activity in the body. However most modern herbalists no longer believe that sarsaparilla cures syphilis, build muscles or cure a flagging libido. There is research to substantiate its use. for gout, arthritis, psoriasis, ulcerative colitis and eczema. Certain root phytochemicals, called saponins, have soothed psoriasis, most likely by disabling bacterial components called endotoxins. Endotoxins show up in the bloodstreams of people with psoriasis, arthritis and gout.If you have any of these conditions, and feel the need for an all-around tonic to help you fight stress sarsaparilla could certainly play a beneficial role.

It was thought by Central Americans to have medicinal properties, and was a popular European treatment for syphilis when it was introduced from the New World. From 1820 to 1910, it was registered in the U.S. Pharmacopoeia as a treatment for syphilis. Modern users claim that it is effective for eczema, psoriasis, arthritis, herpes, and leprosy, along with a variety of other complaints. No peer reviewed research is available for these claims. However, there is peer reviewed research suggesting that it has anti-oxidant properties, like many other herbs.

Other Uses
Sarsaparilla is used as the basis for a soft drink sold for its taste, frequently of the same name, or called Sasparilla. It is also a primary ingredient in old fashioned root beer, in conjunction with Sassafras, more widely available prior to studies of the potential health risks of sassafras.

Sarsaparilla is not readily available in most countries, although many pubs and most major supermarket chains in Malaysia, The United Kingdom and Australia stock sarsaparilla flavored soft drinks. In Malaysia, it is called “Sarsi” amongst many other names. In America, the prevalent brand is Sioux City Sarsaparilla.[citation needed] In Taiwan, HeySong Sarsaparilla soda is also commonly available for purchase from convenience stores and street vendors.

Sarsaparilla was a popular drink in the Old West.

Research:
Sarsaparilla contains steroidal saponins, such as sarsasapogenin, which some researcher claim can duplicate the action of some human hormones. However, this purported property of sarsaparilla remains has not been substantiated by empirical evidence.

Sarsaparilla also contains beta-sitosterol, a phytosterol, which may contribute to the anti-inflammatory property of this herb. A few reports suggest that sarsaparilla has both anti-inflammatory and liver-protecting effects. Similar findings on the effect of sarsaparilla on psoriasis can also be found in European literature.

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Disclaimer:The information presented herein is intended for educational purposes only. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider.

Resources:
http://www.houseofnutrition.com/sarsaparilla.html
http://zipcodezoo.com/Plants/S/Smilax_pumila/
http://en.wikipedia.org/wiki/Smilax_regelii
http://www.anniesremedy.com/herb_detail297.php

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Diagnonistic Test

Percutaneous Transhepatic Cholangiography (PTCA)

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Definition:

Percutaneous transhepatic cholangiography (PTHC or PTC) is a radiologic technique used to visualize the anatomy of the biliary tract. A contrast medium is injected into a bile duct in the liver, after which X-rays are taken. It allows access to the biliary tree in cases where endoscopic retrograde cholangiopancreatography (ERCP) has been unsuccessful. Initially reported in 1937, the procedure became popular after a 1952 report in the English-language literature.

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It is an x-ray test that can help show whether there is a blockage in the liver or the bile ducts that drain it. Since the liver and its drainage system do not normally show up on x-rays, the doctor doing the x-ray needs to inject a special dye directly into the drainage system of the liver. This dye, which is visible on x-rays, should then spread out to fill the whole drainage system. If it does not, that means there is a blockage. This type of blockage might result from a gallstone or a cancer in the liver.

It is predominatly now performed as a therapeutic technique. There are less invasive means of imaging the biliary tree including transabdominal ultrasound, MRCP, computed tomography and endoscopic ultrasound. If the biliary system is obstructed, PTC may be used to drain bile until a more permanent solution for the obstruction is performed (e.g. surgery). Additionally, self expanding metal stents can be placed across malignant biliary strictures to allow palliative drainage. Percutaneous placement of metal stents can be utilised when therapeutic ERCP has been unsuccessful, anatomy is altered precluding endoscopic access to the duodenum, or where there has been separation of the segmental biliary drainage of the liver, allowing more selective placement of metal stents. It is generally accepted that percutanous biliary procedures have higher complication rates than therapeutic ERCP. Complications encountered include infection, bleeding and bile leaks.
Why the test is performed?
Bile is a by-product of protein metabolism. It is created in the liver and excreted into the intestines via the bile ducts. If bile cannot be removed from the body, it collects in the blood and is seen as a yellow discoloration of the skin and eyes (jaundice).

Also, the pancreas creates digestive fluids which drain via a common bile duct into the intestine, and thus obstruction can prevent the drainage of the fluids and may cause pancreatitis (inflammation of the pancreas).

A PTCA test can help identify whether a blockage is causing the jaundice and pancreatitis.

How do you prepare for the test?
Tell your doctor if you have ever had an allergic reaction to lidocaine or the numbing medicine used at the dentist’s office. Also tell your doctor if you could be pregnant. If you have diabetes and take insulin, discuss this with your doctor before the test.

Most people need to have a blood test done some time before the procedure, to make sure they are not at high risk for bleeding complications. If you take aspirin, nonsteroidal anti-inflammatory drugs, or other medicines that affect blood clotting, talk with your doctor. It may be necessary to stop or adjust the dose of these medicines before your test.

You will be told not to eat anything on the morning of the test so that your stomach is empty. This is a safety measure in the unlikely case you have a complication, such as bleeding, that might require repair surgery.

What happens when the test is performed?
You lie on a table wearing a hospital gown. An IV (intravenous) line is inserted into a vein in case you need medicines or fluid during the procedure. An area over your right ribcage is cleaned with an antibacterial soap. Then the radiologist may take a picture of your abdomen with an overhead camera. Medicine is injected through a small needle to numb the skin and the tissue underneath the skin in the area where the dye is to be injected. You may feel some brief stinging from the numbing medicine.

A separate needle is then inserted between two of your ribs on your right side. A small amount of xray dye is injected, and some pictures are taken that are visible on a video screen. Your doctor adjusts the placement of the needle until it is clear that the dye is flowing easily through the ducts (drainage tubes) inside your liver.

Because taking the x-ray pictures sometimes requires a significant amount of time, the doctor replaces the needle with a softer plastic tube. First, the syringe holding the dye is detached from the top of the needle, leaving the needle in place. The doctor then gently pushes a thin wire through the needle and into the duct where the needle has been sitting. Next the needle is pulled out, sliding over the outside end of the wire. The wire is left with one end inside the liver to hold the position where the needle had been. A thin plastic tube similar to an IV line is slid along the wire, like a long bead on a string, until it is in the same place where the needle was. The wire is then pulled out, and the dye syringe is attached to the tube.

More dye is injected through the plastic tube, and pictures are taken with the video camera as the dye spreads inside the liver. If there is no blockage, the dye drains out of the liver through the bile ducts and begins to show up on the x-ray in the area of your small intestine. Once all of the needed pictures have been taken, the plastic tube is pulled out, and a small bandage is placed over your side. The whole test usually takes less than an hour.

Risk Factors:
It is possible to have serious bleeding from this test. In some cases, blood leaks to the outside surface of the liver and causes a buildup of blood there. In other cases, blood can leak directly into the liver’s drainage system, in which case it might start showing up in your intestine, causing a bloody bowel movement. It is less likely that you could develop an infection after the test. The only soreness you are likely to have is at the skin surface where the needle went in. This should last for only a day or two.

In rare cases, the dye used in the test can damage your kidneys. This kidney effect is almost always temporary, but some people have permanent damage.

As with all x-rays, there is a small exposure to radiation. In large amounts, exposure to radiation can cause cancers or (in pregnant women) birth defects. The amount of radiation from the video x-ray in this test is very small-too small to be likely to cause any harm. (The people performing the test on you will wear lead shields, since they would otherwise be exposed to this radiation over and over, which could be more of a danger.)

Must you do anything special after the test is over?
Call your doctor right away if you have pain in your right abdomen or shoulder, fever, dizziness, or a change in your stool color to black or red.

How long is it before the result of the test is known?
You may be told a few early results of your test as soon as the test is done. It takes a day or two for the radiologist to review the x-rays more thoroughly and to give your doctor a full report.

RESULTS:-

Normal Result:-The bile ducts are normal in size and appearance for the age of the patient.

Abnormal Results:-The results may show that the ducts are enlarged, which may indicate the ducts are blocked. The blockage may be caused by infection, scarring, or stones. It may also indicate cancer in the bile ducts, liver, pancreas, or region of the gallbladder.

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*Blocked bile ducts
*Cholangitis (infection in common bile duct)
Special considerations:-
A PTCA may be done if an endoscopic retrograde cholangiopancreatography ( ERCP) cannot be performed or has failed in the past.

An MRCP (magnetic resonance cholangiopancreatography) is a newer, non-invasive imaging method, based on MRI, which provides similar views of the bile ducts.

Resources:
https://www.health.harvard.edu/fhg/diagnostics/percutaneous-transhepatic-cholangiography.shtml
http://en.wikipedia.org/wiki/Percutaneous_transhepatic_cholangiography
http://www.healthline.com/adamcontent/percutaneous-transhepatic-cholangiogram

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Ailmemts & Remedies

Lymphatic Filariasis(Elephantiasis)

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Lymphatic Filariasis (LF), also known as elephantiasis, is a severely disfiguring disease which affects 120m around the world.

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LF causes severe swelling in the limbs

It can be treated, but the drugs are not always available to those most at need.

What are the symptoms?

The condition is associated with huge and disfiguring enlargement of a limb, or areas of the trunk or head. These swellings are known technically as lymphoedema.

In addition, the skin usually develops a thickened, pebbly appearance and may become ulcerated and darkened.

Other symptoms can include fever, chills and a general feeling of ill health.

The disease may also affect the sexual organs. In a man, the scrotum may become enlarged, and the penis may be retracted under the skin.

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In women the external genitalia may be covered in a tumourous mass.

People with the condition often have to contend with social as well as physical problems.

Communities frequently shun women and men disfigured by the disease.

Many women with visible signs of the disease will never marry, or their spouses and families will reject them.

They are also frequently are unable to work because of their disability.

Other symptoms can include fever, chills and a general feeling of ill health.

The disease may also affect the sexual organs. In a man, the scrotum may become enlarged, and the penis may be retracted under the skin.

In women the external genitalia may be covered in a tumourous mass.

People with the condition often have to contend with social as well as physical problems.

Communities frequently shun women and men disfigured by the disease.

Many women with visible signs of the disease will never marry, or their spouses and families will reject them.

They are also frequently are unable to work because of their disability.

What causes it?

It is caused by microscopic, thread-like parasitic worms invading the body’s lymphatic system – the network of vessels carrying infection-fighting cells.

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The worm is spread by mosquitoes, who pass it on when they take blood from humans.

The bacteria-containing worms lodge in the lymphatic system, producing millions of minute larvae which spread throughout the bloodstream.

Image of the worm that causes the disease
Parasitic worms cause the disease

These worms disrupt the balance of the lymphatic system, which helps maintain the fluid balance between the tissues and the blood.

What is still not clear is how much this is down to the worms causing obstruction of the lymphatic vessels, or the immune response their presence triggers in the body.

However, once the tissues have been damaged, they also become vulnerable to other bacterial and fungal infections, which are often responsible for much of the disease seen in LF patients.

Recent studies have also suggested that the disease may be caused by the red soil on which certain barefooted populations live.

It is believed that small chemical particles found in the soil may enter the skin through the bare feet, lodging in the lymphatic tissues and producing irritation which increases the vulnerability to bacterial infection.

Who is most at risk?

Over 120 million have already been affected by it, over 40 million of them are seriously incapacitated and disfigured by the disease.

One-third of the people infected with the disease live in India, one third are in Africa and most of the remainder are in South Asia, the Pacific and the Americas.

In communities where the condition is endemic, 10-50% of men and up to 10% of women can be affected.

Though the infection is generally acquired early in childhood, the disease may take years to manifest itself.

Diagnosis:
The standard method for diagnosing active infection is by finding the microfilariae via microscopic examination. This may be difficult, as in most parts of the world, microfilariae only circulate in the blood at night. For this reason, the blood has to be collected nocturnally.The blood should be in the form of a thick smear and stained with Giemsa. Testing the blood for antibodies against the disease may also be used.

How is it treated?

Drugs such as albendazole and diethylcarbamazine (DEC) have been shown to be effective in killing the parasites.

Their use not only eases symptoms, particularly among people in the early stages of disease, but also prevents the parasites being spread to others in the community.

A study in the Lancet, published in 2005, found that doxycycline, a widely available antibiotic, is also highly effective at killing the parasites.

Careful cleansing can also have a significant impact, helping to heal infected areas, and reversing some of the tissue damage, particularly that associated with secondary bacterial or fungal infections.

Measures to improve the flow of the lymphatic fluid, such as raising and exercising the swollen body part can also help.
Prevention:
Studies have demonstrated transmission of the infection can be broken when a single dose of combined oral medicines is consistently maintained annually, for approximately seven years. With consistent treatment, and since the disease needs a human host, the reduction of microfilariae means the disease will not be transmitted, the adult worms will die out, and the cycle will be broken.

The strategy for eliminating transmission of lymphatic filariasis is mass distribution of medicines that kill the microfilariae and stop transmission of the parasite by mosquitoes in endemic communities. In sub-Saharan Africa, albendazole (donated by GlaxoSmithKline) is being used with ivermectin (donated by Merck & Co.) to treat the disease, whereas elsewhere in the world, albendazole is used with diethylcarbamazine. Using a combination of treatments better reduces the number of microfilariae in blood. Avoiding mosquito bites, such as by using insecticide-treated mosquito bed nets, also reduces the transmission of lymphatic filariasis.

In 1993, the International Task Force for Disease Eradication declared lymphatic filariaisis to be one of six potentially eradicable diseases.

According to medical experts, the worldwide efforts to eliminate lymphatic filariasis is on track to potentially succeed by 2020. An estimated 6.6 million children have been prevented from being infected, with another estimated 9.5 million in whom the progress of the disease has been stopped.

For podoconiosis, international awareness of the disease will have to increase before elimination is possible. In 2011, podoconiosis was added to the World Health Organization’s Neglected Tropical Diseases list, which was an important milestone in raising global awareness of the condition.

The efforts of the Global Programme to Eliminate LF are estimated to have prevented 6.6 million new filariasis cases from developing in children between 2000 and 2007, and to have stopped the progression of the disease in another 9.5 million people who had already contracted it. Dr. Mwele Malecela, who chairs the programme, said: “We are on track to accomplish our goal of elimination by 2020.” In 2010, the WHO published a detailed progress report on the elimination campaign in which they assert that of the 81 countries with endemic LF, 53 have implemented mass drug administration, and 37 have completed five or more rounds in some areas, though urban areas remain problematic.

Prognosis:
About 40 million disfigured and incapacitated by the disease. Elephantiasis caused by lymphatic filariasis is one of the most common causes of disability in the world. In endemic communities, approximately 10 percent of women can be affected with swollen limbs, and 50 percent of men can have from mutilating genital disease. In areas endemic for podoconiosis, prevalence can be 5% or higher.

Researchs:
University of Illinois at Chicago (UIC) inventors have developed a novel vaccine for the prevention of lymphatic filariasis. This vaccine has been shown to elicit strong, protective immune responses in mouse models of lymphatic filariasis infection.The immune response elicited by this vaccine has been demonstrated to be protective against both W. bancrofti and B. malayi infection.

On September 20, 2007, geneticists mapped the genome (genetic content) of Brugia malayi, the roundworm which causes elephantiasis (lymphatic filariasis). Determining the content of the genes might lead to development of new drugs and vaccines.

You may click to see:->Filaria

Resources:
BBC NEWS:nov 14,’06
http://en.wikipedia.org/wiki/Lymphatic_filariasis

 

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