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How Much Exercise Do Children Need?

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YOU’RE a parent and you want to do your best to be sure your children are healthy. So you worry about physical activity. How much exercise is enough? Will being active protect them against diabetes, cancer or heart disease later in life? Will it prevent them from getting fat?

You search for information, for official guidelines on physical activity. And, you soon discover, there is plenty of advice — at least 27 sets of official guidelines, notes Harold W. Kohl, an epidemiologist at the University of Texas School of Public Health in Austin who formerly worked at the Centers for Disease Control and Prevention.

But the problem in making recommendations is a lack of good data.

We can’t “clarify the dose of physical activity and exercise that’s good for kids” as precisely as we think we can, Dr. Kohl said.

It’s not that experts haven’t tried.

For example, a few years ago the C.D.C. convened a panel of experts to review published papers and make the best recommendations. The panel’s co-chairman, Robert M. Malina, a professor emeritus of kinesiology and health education at the University of Texas at Austin, noted that the group reviewed 850 published papers on the benefits of regular exercise for school-age children and adolescents.

In 2004, the panel concluded by recommending that children and adolescents get 60 minutes of moderate to vigorous physical activity every day. Why 60 minutes and not 30 or 45? It was, Dr. Malina said, “a gut reaction” to the body of evidence.

Now, the Department of Health and Human Services is preparing a new set of guidelines, but most of the same questions remain, Dr. Kohl said. And even though he, Dr. Malina and most other exercise researchers enthusiastically endorse physical activity for everyone, they caution that some of its reputed benefits may be oversold.

In reviewing published papers, the C.D.C. and Human Services panels asked: How good are the data? They learned that, with a few exceptions, for every purported benefit, the evidence was often marginal or equivocal. And, Dr. Malina said, even in situations in which exercise has demonstrable effects, there are marked differences among individuals: some children will get more benefit than others and some will not get any at all.

The undisputed benefits of exercise, the panels said, are that it can lead to stronger muscles, greater endurance, and bones that are denser and have greater mineral content. In addition, when obese children exercise regularly, their body fat, blood lipids and blood pressure may fall. Exercise, though, has not been found to have those effects on healthy children of normal weight.

Even there, though, uncertainties remain, Dr. Kohl said. “Kids aren’t little adults, and they don’t do things for 30 minutes straight through,” he said. “You can put kids on treadmills and train them and that can somewhat help obese kids reduce their adiposity levels, but when you get out in the real world it’s not that easy.”

The panels asked whether exercise alleviates symptoms of anxiety or depression or whether it improves self-image. The studies were not large enough to draw conclusions, they said.

Another issue is academics. Do physically active and physically fit children do better in school? Do they have qualities, like an improved ability to pay attention, that might predict better academic performance?

The answer, Dr. Kohl said, is not known. “The only good data we have indicate that participation in a better physical education program does not negatively affect test scores,” he adds.

Parents sometimes are advised to get children involved in activities that they can do throughout a lifetime — walking, cycling or swimming. But, Dr. Malina said, there is no good evidence that the sport someone does as a child will affect activity as an adult.

“The evidence that tracks youngsters to adulthood is very relatively meager,” Dr. Malina said. And, he added, it is not clear how and why people change activities during their lives.

“I played all sorts of sports growing up,” he said. By the time he started college, he adds, “baseball was my sport.” Now, said Dr. Malina, who is 71, “in my old age, my activity is walking.”

Still, exercise researchers do have some advice for parents: Let the children decide what physical activity they want to do.

“The single best activity you can do is the one you will do,” said Charles B. Corbin, a professor emeritus in the department of exercise and wellness at Arizona State University and the author of more than 80 books on fitness.

And the mistake parents often make, Dr. Malina said, is to decide in advance which sports their children should pursue.

“All too often, youngsters do not have a choice in the decision-making process,” he explained. And, he said, no matter how much parents may want their children to be physically active, “if it is not fun, the child will not do it.”

Sources: The New York Times

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Ailmemts & Remedies

Hypoglycemia

Definition:
Hypoglycemia is the clinical syndrome that results from low blood sugar. The symptoms of hypoglycemia can vary from person to person, as can the severity. Classically, hypoglycemia is diagnosed by a low blood sugar with symptoms that resolve when the sugar level returns to the normal range….CLICK & SEE

Risk Factor:
While patients who do not have any metabolic problems can complain of symptoms suggestive of low blood sugar, true hypoglycemia usually occurs in patients being treated for diabetes (type 1 and type 2). Patients with pre-diabetes who have insulin resistance can also have low sugars on occasion if their high circulating insulin levels are further challenged by a prolonged period of fasting. There are other rare causes for hypoglycemia, such as insulin producing tumors (insulinomas) and certain medications. These uncommon causes of hypoglycemia will not be discussed in this article, which will primarily focus on the hypoglycemia occurring with diabetes mellitus and its treatment.

Despite our advances in the treatment of diabetes, hypoglycemic episodes are often the limiting factor in achieving optimal blood sugar control. In large scale studies looking at tight control in both type 1 and type 2 diabetes, low blood sugars occurred more often in the patients who were managed most intensively. This is important for patients and physicians to recognize, especially as the goal for treating patients with diabetes become tighter blood sugar control.

Low Blood sugar is Also Bad:
The body needs fuel to work. One of its major fuel sources is sugars, which the body gets from what is consumed as either simple sugar or complex carbohydrates. For emergency situations (like prolonged fasting), the body stores a stash of sugar in the liver as glycogen. If this store is needed, the body goes through a biochemical process called gluco-neo-genesis (meaning to “make new sugar”) and converts these stores of glycogen to sugar. This backup process emphasizes that the fuel source of sugar is important (important enough for human beings to have developed an evolutionary system of storage to avoid a sugar drought).

Of all the organs in the body, the brain depends on sugar (which we are now going to refer to as glucose) almost exclusively. Rarely, if absolutely necessary, the brain will use ketones as a fuel source, but this is not preferred. The brain cannot make its own glucose and is 100% dependent on the rest of the body for its supply. If for some reason, the glucose level in the blood falls (or if the brain’s requirements increase and demands are not met) there can be effects on the function of the brain.

Our Body’s Natural Protection:
When the circulating level of blood glucose falls, the brain actually senses the drop. The brain then sends out messages that trigger a series of events, including changes in hormone and nervous system responses that are aimed at increasing blood glucose levels. Insulin secretion decreases and hormones that promote higher blood glucose levels, such as glucagon, cortisol, growth hormone and epinephrine, all increase. As mentioned above, there is a store in the liver of glycogen that can be converted to glucose rapidly.

In addition to the biochemical processes that occur, the body starts to consciously alert the affected person that is needs food by causing the signs and symptoms of hypoglycemia discussed below.

Signs and symptoms:
Hypoglycemic symptoms and manifestations can be divided into those produced by the counterregulatory hormones (epinephrine/adrenaline and glucagon) triggered by the falling glucose, and the neuroglycopenic effects produced by the reduced brain sugar.

Adrenergic manifestations

*Shakiness, anxiety, nervousness, tremor

*Palpitations, tachycardia

*Sweating, feeling of warmth

*Pallor, coldness, clamminess

*Dilated pupils (mydriasis)

Feeling of numbness “pins and needles” (parasthaesia) in the fingers

Glucagon manifestations:

*Hunger, borborygmus

*Nausea, vomiting, abdominal discomfort

*Headache

Neuroglycopenic manifestations:

*Abnormal mentation, impaired judgement

*Nonspecific dysphoria, anxiety, moodiness, depression, crying

*Negativism, irritability, belligerence, combativeness, rage

*Personality change, emotional lability

*Fatigue, weakness, apathy, lethargy, daydreaming, sleep

*Confusion, amnesia, dizziness, delirium

*Staring, “glassy” look, blurred vision, double vision

*Automatic behavior, also known as automatism

*Difficulty speaking, slurred speech

*Ataxia, incoordination, sometimes mistaken for “drunkenness”

*Focal or general motor deficit, paralysis, hemiparesis

*Paresthesia, headache

*Stupor, coma, abnormal breathing

*Generalized or focal seizures

Not all of the above manifestations occur in every case of hypoglycemia. There is no consistent order to the appearance of the symptoms, if symptoms even occur. Specific manifestations may vary by age and by severity of the hypoglycemia. In young children, vomiting can sometimes accompany morning hypoglycemia with ketosis. In older children and adults, moderately severe hypoglycemia can resemble mania, mental illness, drug intoxication, or drunkenness. In the elderly, hypoglycemia can produce focal stroke-like effects or a hard-to-define malaise. The symptoms of a single person may be similar from episode to episode, but are not necessarily so and may be influenced by the speed at which glucose levels are dropping, and previous incidence.

In newborns, hypoglycemia can produce irritability, jitters, myoclonic jerks, cyanosis, respiratory distress, apneic episodes, sweating, hypothermia, somnolence, hypotonia, refusal to feed, and seizures or “spells”. Hypoglycemia can resemble asphyxia, hypocalcemia, sepsis, or heart failure.

In both young and old patients, the brain may habituate to low glucose levels, with a reduction of noticeable symptoms despite neuroglycopenic impairment. In insulin-dependent diabetic patients this phenomenon is termed hypoglycemia unawareness and is a significant clinical problem when improved glycemic control is attempted. Another aspect of this phenomenon occurs in type I glycogenosis, when chronic hypoglycemia before diagnosis may be better tolerated than acute hypoglycemia after treatment is underway.

Nearly always, hypoglycemia severe enough to cause seizures or unconsciousness can be reversed without obvious harm to the brain. Cases of death or permanent neurological damage occurring with a single episode have usually involved prolonged, untreated unconsciousness, interference with breathing, severe concurrent disease, or some other type of vulnerability. Nevertheless, brain damage or death has occasionally resulted from severe hypoglycemia.

Causes:-
Hundreds of conditions can cause hypoglycemia. Common causes by age are listed below. While many aspects of the medical history and physical examination may be informative, the two best guides to the cause of unexplained hypoglycemia are usually

1.The circumstances

2.A critical sample of blood obtained at the time of hypoglycemia, before it is reversed.

There are several ways to classify hypoglycemia. The following is a list of the more common causes and factors which may contribute to hypoglycemia grouped by age, followed by some causes that are relatively age-independent. See causes of hypoglycemia for a more complete list grouped by etiology.

Hypoglycemia in newborn infants:-

Hypoglycemia is a common problem in critically ill or extremely low birthweight infants. If not due to maternal hyperglycemia, in most cases it is multifactorial, transient and easily supported. In a minority of cases hypoglycemia turns out to be due to significant hyperinsulinism, hypopituitarism or an inborn error of metabolism and presents more of a management challenge.

*Transient neonatal hypoglycemia

*Prematurity, intrauterine growth retardation, perinatal asphyxia

*Maternal hyperglycemia due to diabetes or iatrogenic glucose administration

*Sepsis

*Prolonged fasting (e.g., due to inadequate breast milk or condition interfering with feeding)

*Congenital hypopituitarism

*Congenital hyperinsulinism, several types, both transient and persistent

*Inborn errors of carbohydrate metabolism such as glycogen storage disease

Hypoglycemia in young children:-

Single episodes of hypoglycemia may occur due to gastroenteritis or fasting, but recurrent episodes nearly always indicate either an inborn error of metabolism, congenital hypopituitarism, or congenital hyperinsulinism. A list of common causes:

*Prolonged fasting

*Diarrheal illness in young children, especially rotavirus gastroenteritis

*Idiopathic ketotic hypoglycemia

*Isolated growth hormone deficiency, hypopituitarism

*Insulin excess

*Hyperinsulinism due to several congenital disorders of insulin secretion

*Insulin injected for type 1 diabetes

*Hyperinsulin Hyperammonia syndrome (HIHA)due toGlutamate dehydrogenase 1gene.Can cause mental retardation and epilepsy in severe cases.

*Gastric dumping syndrome (after gastrointestinal surgery)

*Other congenital metabolic diseases; some of the common include

*Maple syrup urine disease and other organic acidurias

*Type 1 glycogen storage disease

*Type III glycogen storage disease. Can cause less severe hypoglycemia than type I

*Disorders of fatty acid oxidation

*Medium chain acylCoA dehydrogenase deficiency (MCAD)

*Familial Leucine sensitive hypoglycemia

*Accidental ingestions

*Sulfonylureas, propranolol and others

*Ethanol (mouthwash, “leftover morning-after-the-party drinks”)

Hypoglycemia in older children and young adults:-

By far, the most common cause of severe hypoglycemia in this age range is insulin injected for type 1 diabetes. Circumstances should provide clues fairly quickly for the new diseases causing severe hypoglycemia. All of the congenital metabolic defects, congenital forms of hyperinsulinism, and congenital hypopituitarism are likely to have already been diagnosed or are unlikely to start causing new hypoglycemia at this age. Body mass is large enough to make starvation hypoglycemia and idiopathic ketotic hypoglycemia quite uncommon. Recurrent mild hypoglycemia may fit a reactive hypoglycemia pattern, but this is also the peak age for idiopathic postprandial syndrome, and recurrent “spells” in this age group can be traced to orthostatic hypotension or hyperventilation as often as demonstrable hypoglycemia.

*Insulin-induced hypoglycemia

*Insulin injected for type 1 diabetes

*Factitious insulin injection (Munchausen syndrome)

*Insulin-secreting pancreatic tumor

*Reactive hypoglycemia and idiopathic postprandial syndrome

*Addison’s disease

*Sepsis

Hypoglycemia in older adults:-

The incidence of hypoglycemia due to complex drug interactions, especially involving oral hypoglycemic agents and insulin for diabetes rises with age. Though much rarer, the incidence of insulin-producing tumors also rises with advancing age. Most tumors causing hypoglycemia by mechanisms other than insulin excess occur in adults.

*Insulin-induced hypoglycemia

*Insulin injected for diabetes

*Factitious insulin injection (Munchausen syndrome)

*Excessive effects of oral diabetes drugs, beta-blockers, or drug interactions

*Insulin-secreting pancreatic tumor

*Alimentary (rapid jejunal emptying with exaggerated insulin response)

*After gastrectomy dumping syndrome or bowel bypass surgery or resection

*Reactive hypoglycemia and idiopathic postprandial syndrome

*Tumor hypoglycemia, Doege-Potter syndrome

*Acquired adrenal insufficiency

*Acquired hypopituitarism

*Immunopathologic hypoglycemia

Treatment:-
Management of hypoglycemia involves immediately raising the blood sugar to normal, determining the cause, and taking measures to hopefully prevent future episodes.

Reversing acute hypoglycemia:-
The blood glucose can be raised to normal within minutes by taking (or receiving) 10-20 grams of carbohydrate. It can be taken as food or drink if the person is conscious and able to swallow. This amount of carbohydrate is contained in about 3-4 ounces (100-120 ml) of orange, apple, or grape juice although fruit juices contain a higher proportion of fructose which is more slowly metabolized than pure dextrose, alternatively, about 4-5 ounces (120-150 ml) of regular (non-diet) soda may also work, as will about one slice of bread, about 4 crackers, or about 1 serving of most starchy foods. Starch is quickly digested to glucose (unless the person is taking acarbose), but adding fat or protein retards digestion. Symptoms should begin to improve within 5 minutes, though full recovery may take 10-20 minutes. Overfeeding does not speed recovery and if the person has diabetes will simply produce hyperglycemia afterwards.

If a person is suffering such severe effects of hypoglycemia that they cannot (due to combativeness) or should not (due to seizures or unconsciousness) be given anything by mouth, medical personnel such as EMTs and Paramedics, or in-hospital personnel can establish an IV and give intravenous Dextrose, concentrations varying depending on age (Infants are given 2cc/kg Dextrose 10%, Children Dextrose 25%, and Adults Dextrose 50%). Care must be taken in giving these solutions because they can be very necrotic if the IV is infiltrated. If an IV cannot be established, the patient can be given 1 to 2 milligrams of Glucagon in an intramuscular injection. More treatment information can be found in the article diabetic hypoglycemia.

One situation where starch may be less effective than glucose or sucrose is when a person is taking acarbose. Since acarbose and other alpha-glucosidase inhibitors prevents starch and other sugars from being broken down into monosaccharides that can be absorbed by the body, patients taking these medications should consume monosaccharide-containing foods such as glucose tablets, honey, or juice to reverse hypoglycemia.

Prevention:
The most effective means of preventing further episodes of hypoglycemia depends on the cause.

The risk of further episodes of diabetic hypoglycemia can often (but not always) be reduced by lowering the dose of insulin or other medications, or by more meticulous attention to blood sugar balance during unusual hours, higher levels of exercise, or alcohol intake.

Many of the inborn errors of metabolism require avoidance or shortening of fasting intervals, or extra carbohydrates. For the more severe disorders, such as type 1 glycogen storage disease, this may be supplied in the form of cornstarch every few hours or by continuous gastric infusion.

Several treatments are used for hyperinsulinemic hypoglycemia, depending on the exact form and severity. Some forms of congenital hyperinsulinism respond to diazoxide or octreotide. Surgical removal of the overactive part of the pancreas is curative with minimal risk when hyperinsulinism is focal or due to a benign insulin-producing tumor of the pancreas. When congenital hyperinsulinism is diffuse and refractory to medications, near-total pancreatectomy may be the treatment of last resort, but in this condition is less consistently effective and fraught with more complications.

Hypoglycemia due to hormone deficiencies such as hypopituitarism or adrenal insufficiency usually ceases when the appropriate hormone is replaced.

Hypoglycemia due to dumping syndrome and other post-surgical conditions is best dealt with by altering diet. Including fat and protein with carbohydrates may slow digestion and reduce early insulin secretion. Some forms of this respond to treatment with a glucosidase inhibitor, which slows starch digestion.

Reactive hypoglycemia with demonstrably low blood glucose levels is most often a predictable nuisance which can be avoided by consuming fat and protein with carbohydrates, by adding morning or afternoon snacks, and reducing alcohol intake.

Idiopathic postprandial syndrome without demonstrably low glucose levels at the time of symptoms can be more of a management challenge. Many people find improvement by changing eating patterns (smaller meals, avoiding excessive sugar, mixed meals rather than carbohydrates by themselves), reducing intake of stimulants such as caffeine, or by making lifestyle changes to reduce stress.

Herbal medication for Hypoglycemia:-
THE following HERBS as stated below can help to ease low blood sugar with symptoms that include lightheadedness, headache, irritability, depression, anxiety, cravings for sweets, confusion, night sweats, weakness in the legs and arms, swollen feet, insatiable hunger, eye pain, nervous tics, mental disturbances, insomnia, aggressiveness, hair-trigger temper.

Cinnamon bark extract, coral calcium with trace minerals, L-carnitine, bilberry extract, Mexican wild yam, dandelion root, milk thistle extract.

Quik Tip: Cinnamon bark decreases insulin resistance and improves blood-sugar profiles better than most prescription drugs, USDA studies confirm.

Hypoglycemia as “folk” medicine:-
Hypoglycemia is also a term of contemporary folk medicine which refers to a recurrent state of symptoms of altered mood and subjective cognitive efficiency, sometimes accompanied by adrenergic symptoms, but not necessarily by measured low blood glucose. Symptoms are primarily those of altered mood, behavior, and mental efficiency. This condition is usually treated by dietary changes which range from simple to elaborate. Advising people on management of this condition is a significant “sub-industry” of alternative medicine. More information about this form of “hypoglycemia”, with far more elaborate dietary recommendations, is available on the internet and in health food stores. Most of these websites and books describe a conflation of reactive hypoglycemia and idiopathic postprandial syndrome but do not recognize a distinction. The value of most of their recommendations is – from a scientific perspective – unproved.

Disclaimer: This information is not meant to be a substitute for professional medical advise or help. It is always best to consult with a Physician about serious health concerns. This information is in no way intended to diagnose or prescribe remedies.This is purely for educational purpose.

Resources:
http://www.medicinenet.com/hypoglycemia/article.htm
http://en.wikipedia.org/wiki/Hypoglycemia
http://www.herbnews.org/hypoglycemiadone.htm

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Biotin

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Biotin (vitamin H)

CAS#: 58-85-5

   Molecular Structure:.-> CLICK & SEE

Molecular Formula: C10H16N2O3S

Molecular Weight:244.31

Quality Standard: USP30

Biotin contains not less than 97.5 percent and not more than percent of C10H16N2O3S.

Vitamin H redirects here. In medical slang, Vitamin H may also refer to haloperidol. In gamer slang Vitamin H may also refer to the Halo (series)
Biotin, also known as vitamin H or B7, has the chemical formula C10H16N2O3S (Biotin; Coenzyme R, Biopeiderm), is a water-soluble B-complex vitamin which is composed of an ureido (tetrahydroimidizalone) ring fused with a tetrahydrothiophene ring. A valeric acid substituent is attached to one of the carbon atoms of the tetrahydrothiophene ring. Biotin is a cofactor in the metabolism of fatty acids and leucine, and in gluconeogenesis.

Biotin is a B vitamin that’s needed for the formation of fatty acids and glucose, which are essential for the production of energy. It also helps with the metabolism of carbohydrates, fats and proteins.

Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids. It plays a role in the Citric acid cycle, which is the process by which biochemical energy is generated during aerobic respiration. Biotin not only assists in various metabolic reactions, but also helps to transfer carbon dioxide. Biotin is also helpful in maintaining a steady blood sugar level. Biotin is often recommended for strengthening hair and nails. Consequently, it is found in many cosmetic and health products for the hair and skin.

Deficiency is extremely rare, as intestinal bacteria generally produce an excess of the body’s daily requirement. For that reason, statutory agencies in many countries (e.g., the Australian Department of Health and Aging) do not prescribe a recommended daily intake.

Biotin deficiency isn’t common, unless you frequently eat a lot of raw egg white, which contains a protein that blocks the absorption of biotin. Genetic disorder of biotin deficiency, infant seborrheic dermatitis, surgical removal of the stomach, and excessive alcohol consumption may increase a person’s requirement for biotin.

Biotin deficiency may lead to skin rash, hair loss, high cholesterol and heart problems.

Sources:
Dietary
Biotin is widely distributed in a variety of foods, but most often at low concentrations. Estimates are that the typical U.S. diet provides roughly 40 mcg/day. There are only a couple of foods which contain biotin in large amounts, including royal jelly and brewer’s yeast. The most important natural sources of biotin in human nutrition are milk, liver, egg (egg yolk), and some vegetables.Biotin is found naturally in food. Good dietary sources of biotin include brewer’s yeast, nutritional yeast, cauliflower, salmon, bananas, carrots,  sardines, legumes and mushrooms.

The most important natural sources in feeding nonruminant animals are oilseed meals, alfalfa, and dried yeasts. It is important to note that the biotin content of food varies and can be influenced by factors such as plant variety, season, and yield (endosperm-to-pericarp ratio).

Adequate intake are determined for nutrients when there is insufficient scientific evidence to establish a Recommended Dietary Allowance (RDA). These values are set as goals for individuals to support adequate nutritional status. NOTE: U.S. Food and supplement labels show 30 mcg of biotin as providing only 10% DV (Daily Value) because DVs are based on older and in some instances outdated RDAs for nutrients. Thus, the DV for biotin is 300 mcg even though there is now consensus that 30 mcg is adequate. There is no current Tolerable Upper Limit (UL) set for biotin as research has indicated that high levels of intake by humans has no detrimental effects.

Bioavailability
Studies on the bioavailability of biotin have been conducted in rats and in chicks. From these studies, it was concluded that biotin bioavailability may be low or variable depending on the type of food being consumed, but in general, approximately half of the biotin in most foods is considered to be biologically available. The biotin present in corn is readily available; however, most grain have about a 20-40% bioavailability of biotin .

A possible explanation for the wide variability in biotin bioavailability is that it is due to ability of an organism to break various biotin-protein bonds from food. Whether an organism has an enzyme with the ability to break that bond will determine the bioavailability of biotin from the foodstuff.

Factors that Affect Biotin Requirements
The frequency of marginal biotin status is not known, but the incidence of low circulating biotin levels in alcoholics has been found to be much greater than in the general population. Also, relatively low levels of biotin have been reported in the urine or plasma of patients who have had partial gastrectomy or who have other causes of achlorhydria, burn patients, epileptics, elderly individuals, and athletes. Pregnancy and lactation may be associated with an increased demand for biotin. In pregnancy, this may be due to a possible acceleration of biotin catabolism, whereas in lactation, the higher demand has yet to be elucidated. Recent studies have shown that marginal biotin deficiency can be present in human gestation, as evidenced by increased urinary excretion of 3-hydroxyisovaleric acid, decreased urinary excretion of biotin and bisnorbiotin, and decreased plasma concentration of biotin. Additionally, smoking may further accelerate biotin catabolism in women.

Medicinal Uses:

Hair Problems
Biotin supplements are often recommended as a natural product to counteract the problem of hair loss in both children and adults. There are, however, no studies that show any benefit in any case where the subject is not actually biotin deficient. The signs and symptoms of biotin deficiency include hair loss which progresses in severity to include loss of eye lashes and eye brows in severely deficient subjects. Some shampoos are available that contain biotin, but it is doubtful whether they would have any useful effect, as biotin is not absorbed well through the skin.

Cradle cap (seborrheic dermatitis)
Children with a rare inherited metabolic disorder called phenylketonuria (PKU; in which one is unable to break down the amino acid phenylalanine) often develop skin conditions such as eczema and seborrheic dermatitis in areas of the body other than the scalp. The scaly skin changes that occur in people with PKU may be related to poor ability to use biotin. Increasing dietary biotin has been known to improve seborrheic dermatitis[citation needed] in these cases.

Diabetes
People with type 2 diabetes often have low levels of biotin. Biotin may be involved in the synthesis and release of insulin. Preliminary studies in both animals and people suggest that biotin may help improve blood glucose control in those with diabetes, particularly type 2 diabetes. Specifically, biotin doses in excess of nutritional requirements lower postprandial glucose and improve glucose tolerance.

Deficiency:-
Biotin deficiency is relatively rare and mild, and can be addressed with supplementation. Such deficiency can be caused by the excessive consumption of raw egg whites, which contain high levels of the protein avidin, which binds biotin strongly. Avidin is deactivated by cooking, while the biotin remains intact.

Biotinidase deficiency is not due to inadequate biotin, but rather to a deficiency in the enzymes which process it.

Signs of Biotin Deficiency: In general, appetite and growth are decreased. Dermatologic symptoms include dermatitis, alopecia, and achromotrichia (absence or loss of pigment in the hair). Perosis (a shortening and thickening of bones) is seen in the skeleton. FLKS (fatty liver and kidney syndrome) and hepatic steatosis also can occur.

Toxicity
Animal studies have indicated few, if any, effects due to toxic doses of biotin. This may provide evidence that both animals and humans may tolerate doses of at least an order of magnitude greater than each of their nutritional requirements. There are no reported cases of adverse effects from receiving high doses of the vitamin, particularly when used in the treatment of metabolic disorders causing sebhorrheic dermatitis in infants.

Side Effects and Safety Concerns:-
The safety of biotin supplements in pregnant or nursing women, children or people with liver or kidney disease isn’t known.

People with a history of seizures shouldn’t use biotin unless under the supervision of a qualified health practitioner

Resources:
http://altmedicine.about.com/cs/herbsvitaminsa1/a/Biotin.htm#
http://en.wikipedia.org/wiki/Biotin.
http://www.sciphar.com/Vitamin%20Series%20&%20derivative/Biotin%20(vitamin%20H).asp

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Apple Cider Vinegar

Other names: cider vinegar, ACV, acetic acid

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Apple cider vinegar is a type of vinegar made by the fermentation of apple cider. During this process, sugar in the apple cider is broken down by bacteria and yeast into alcohol and then into vinegar. Apple cider vinegar contains acetic acid (like other types of vinegar) and some lactic, citric and malic acids.

Unlike white vinegar, apple cider vinegar is a light yellow-brown color and is often sold unfiltered and unpasteurized with a dark, cloudy sediment called mother of vinegar (consisting mainly of acetic acid bacteria) settled at the bottom of the bottle.

Unfiltered and unpasteurized apple cider vinegar is sold in health food stores, online and in some grocery stores.

Although other types of vinegar — such as white vinegar, balsamic vinegar, red wine vinegar and rice wine vinegar — are used mainly in cooking, apple cider vinegar is used primarily for health purposes. Hippocrates was said to have used it as a health tonic and American soldiers are said to have used it to combat indigestion, pneumonia and scurvy.

But it wasn’t until the book Folk Medicine: A Vermont Doctor’s Guide to Good Health, written by D.C. Jarvis, M.D., was published in 1958 that the medicinal use of apple cider vinegar took off. Jarvis recommended apple cider vinegar as a cure-all, explaining that it was unusually rich in potassium (compared to other food sources, it is not). He said that mixing the apple cider vinegar with honey, a mixture he called “honegar,” enhanced the healing power of the vinegar. Jarvis also wrote that apple cider vinegar could destroy harmful bacteria in the digestive tract and recommended as a digestive tonic to be consumed with meals.

Although the year it was released it didn’t attract much attention, the following year, Folk Medicine became a bestseller and stayed on the bestseller list for months. According to Time magazine, it sold more than 245,000 copies in a single week and received many testimonials by people who felt they benefited from the apple cider vinegar and honey mixture.

In the 1970s, apple cider vinegar became popular once again, this time by proponents who had read Jarvis’ book and suggested that apple cider vinegar along with kelp, vitamin B6 and lecithin could help people lose weight by speeding metabolism and burning fat at a faster rate.

Why Do People Use Apple Cider Vinegar
Diabetes
Perhaps the most intriguing aspect of apple cider vinegar’s possible health benefits is its effect on blood glucose levels. Several small studies suggest that vinegar (both apple cider vinegar and other types) may help to lower glucose levels.

For example, a preliminary study by researchers at Arizona State University, published in the journal Diabetes Care, examined people with type 2 diabetes. Study participants took either two tablespoons of apple cider vinegar or water with one ounce of cheese at bedtime for two days. The researchers found taking two tablespoons of apple cider vinegar at bedtime had a favorable impact on blood glucose levels the next morning. Prior to the study, the average fasting blood glucose level was 137 mg/dL. It decreased by 2% with the cheese and by 4% with the vinegar, a statistically significant difference. In people with a fasting glucose level above 130 mg/dL prior to the study, the vinegar reduced glucose levels by as much as 6%. The study was very small and the duration was short, so more research is needed.

Other studies have found that vinegar can lower the post-meal rise in glucose. The acetic acid in vinegar is thought to slow starch digestion and reduce the glycemic index of starchy foods. For example, a small study compared the effect of vinegar with white bread on blood glucose and insulin levels. Researchers found that those who took vinegar with white bread had lower post-meal blood glucose and insulin levels and it also appeared to increase satiety ratings.

Weight Loss
Apple cider vinegar has become popular as a “fat-burner” and as a natural appetite suppressant. In fact, there’s even an apple cider vinegar diet, which involves taking one to three teaspoons of apple cider vinegar or apple cider vinegar pills before each meal.

The earliest proponent of apple cider vinegar for weight loss was Jarvis, who wrote that people who consumed apple cider vinegar regularly would burn fat instead of store it. Although some say that the pectin, enzymes, vitamins, or potassium may help with weight loss, there is no reliable research showing that either apple cider vinegar or the combination of apple cider vinegar, kelp, vitamin B6 and lecithin can influence metabolic rate or the help us “burn fat” faster than we normally would.

One small study in 2005 found that those who ate a piece of bread with a small amount of white vinegar felt more full and satisfied than those who ate the bread alone. It’s possible that vinegar may affect satiety by lowering the glycemic index of carbohydrates eaten at a meal. More research is needed.

Alkaline Acid Balance
Some alternative practitioners suggest apple cider vinegar as part of a diet to restore alkaline acid balance. The theory behind the alkaline diet is our blood is slightly alkaline, with a normal pH level of between 7.35 and 7.45. Our diet should reflect this pH level and be slightly alkaline. All foods we eat, after being digested and metabolized, release either an acid or alkaline base (bicarbonate) into blood. The foods that people tend to overeat –- grains, meat, dairy products — all produce acid.

Proponents of the alkaline-acid theory believe that a diet high in acid-producing foods leads to lack of energy, excessive mucous production, infections, anxiety, irritability, headache, sore throat, nasal and sinus congestion, allergic reactions and makes people prone to conditions such as arthritis and gout. Despite being an acidic solution, some proponents of apple cider vinegar believe it has an alkalinizing effect on the body, which is why one to two teaspoons of apple cider vinegar in water is recommended as a daily health tonic. Although it’s a popular remedy, the effectiveness of the remedy and the theory haven’t been researched.

Dandruff
A home remedy for dandruff is to mix 1/4 cup apple cider vinegar with 1/4 cup water. The vinegar solution is thought to restore the restore the pH balance of the scalp and discourage the overgrowth of malassezia furfur, the yeast-like fungus thought to trigger dandruff.

The vinegar mixture is usually poured into a spray bottle and spritzed on the hair and scalp, avoiding the eye and ear area. A towel is then wrapped around the head and left on 15 minutes to an hour. After that, the vinegar can be washed from the hair. Alternative practitioners often recommend it once to twice a week for dandruff.

High Cholesterol
A 2006 study found that rats fed acetic acid (the main ingredient in vinegar) had significantly lower total cholesterol and triglyceride levels. Large, human trials are needed to see if the same results occur in humans.

Acid Reflux
Apple cider vinegar in water is a popular home remedy for acid reflux. It’s based on a theory by some alternative medicine practitioners that heartburn and reflux are actually symptoms of insufficient stomach acid caused by aging, poor diet or overusing antacids or other medications. Alternative practitioners usually rely on laboratories that conduct alternative tests to assess stomach acidity prior to any treatment. Critics say that insufficient stomach acid, or hypochlorhydria, isn’t a common condition and that it isn’t a known cause of acid reflux or heartburn.

Apple cider vinegar isn’t recommended as a home remedy for acid reflux or heartburn, because it may damage the delicate lining of the digestive tract and it could possibly worsen the problem. If you have acid reflux or heartburn, see a qualified health practitioner for a proper diagnosis and treatment.

Acne
Apple cider vinegar is a home remedy for acne. A typical application is one part apple cider vinegar to three parts water and the solution is dabbed onto the pimple. Although some people swear by it, caution should be used because there have been case reports of skin damage and burns from using full-strength vinegar on the face.

Blood Pressure
Preliminary studies suggest that the acetic acid in vinegar may help to lower blood pressure. How it might work is unclear, although studies suggest that it may increase levels of nitric oxide, a compound in the body that relaxes blood vessels, or it might inhibit an enzyme called angiotensin-converting enzyme from producing angiotensin II, a hormone that causes blood vessels to constrict or narrow.

Side Effects and Safety Concerns:
Undiluted apple cider vinegar, in liquid or pill form, may damage the esophagus and other parts of the digestive tract. Apple cider vinegar drinks may damage tooth enamel if sipped.

One case report linked excessive apple cider vinegar consumption with low blood potassium levels (hypokalemia) and low bone mineral density. People with osteoporosis, low potassium levels and those taking potassium-lowering medications should use caution.

People with allergies to apples should avoid apple cider vinegar.

Apple cider vinegar tablets may become lodged in the throat or esophagus and cause serious damage to those tissues.

Vinegar applied to the skin may cause burns and scarring.

Excessive doses of apple cider vinegar have been found to cause damage to the stomach, duodenum and liver in animals.

The quality of apple cider vinegar tablets varies. A 2005 study compared eight brands of apple cider vinegar supplements and found that the ingredients didn’t correspond with the ingredients listed on the packaging, and that the chemical analysis of the samples led researchers to question whether any of the products were actually apple cider vinegar or whether they were just acetic acid.

Possible Drug Interactions:
Theoretically, prolonged use of apple cider vinegar could lead to lower potassium levels, which could increase the risk of toxicity of cardiac glycoside drugs such as Lanoxin (digoxin), insulin, laxatives and diuretics such as Lasix (furosemide).

Because apple cider vinegar may affect blood glucose and insulin levels, it could theoretically have an additive effect if combined with diabetes medications. Apple cider vinegar may also lower blood pressure, so it may have an additive effect if combined with high blood pressure medications.

Click to see more health benefits of Apple Sider Vinegar—>……..(1)………(3)……..(3)…….(4)

Resources:Fushimi T, Suruga K, Oshima Y, Fukiharu M, Tsukamoto Y, Goda T. Dietary acetic acid reduces serum cholesterol and triacylglycerols in rats fed a cholesterol-rich diet. Br J Nutr. (2006) 95.5: 916-924.

Ostman E, Granfeldt Y, Persson L, Björck I. Vinegar supplementation lowers glucose and insulin responses and increases satiety after a bread meal in healthy subjects. Eur J Clin Nutr. (2005) 59.9: 983-988.

White AM, Johnston CS. Vinegar ingestion at bedtime moderates waking glucose concentrations in adults with well-controlled type 2 diabetes. Diabetes Care. (2007) 30.11: 2814-2815.

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Red Wine and Tea Can Help Regulate Your Blood Sugar

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Researchers have shown that red wine and tea may both hold promise for regulating the blood sugar of people with type 2 diabetes.

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Levels of blood glucose rise sharply in patients with type 2 diabetes immediately following a meal. Red wine and tea contain antioxidants that help to slow the passage of glucose through the small intestine and into the bloodstream, which can prevent the blood sugar spike.

Keeping blood sugar levels normal is one of the key challenges of managing diabetes; doing so can help prevent the disease from contributing to heart disease and high blood pressure as well as damaging the eyes, kidneys, nerves and blood vessels.

In the study, researchers tested how well wine and tea could inhibit the activity of a target enzyme called alpha-glucosidase, which is responsible for triggering the absorption of glucose by the small intestine.

Red wine came out on top, as it was able to inhibit the enzyme by nearly 100 percent, compared to white wine at 20 percent.

Out of the four types of tea tested — black, oolong, white and green — black tea was most effective, followed by white tea and oolong tea.
Sources:
Science Daily April 3, 2008
Journal of Food Biochemistry February 2008, Volume 32 Issue 1 Page 15-31

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